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PAPLN - papilin, proteoglycan like sulfated glycoprotein Gene

Also Known as PPN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89932

About PAPLN

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:73,235,805-73,274,623 (from NCBI)

This gene has 12 transcripts (splice variants), 265 orthologues and 25 paralogues. Broad expression in spleen (RPKM 9.2), kidney (RPKM 8.9) and 22 other tissues.

Summary

Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

PAPLN Products (3)

mRNA	Protein	Name
NM_001365906.3	NP_001352835.1	papilin isoform 2 precursor
NM_001365907.2	NP_001352836.1	papilin isoform 3 precursor
NM_173462.4	NP_775733.3	papilin isoform 1 precursor

PAPLN Protein Structure

TSP_1

ADAM_spacer1

TSP_1

Kunitz_BPTI

I-set

PLAC

0
200
400
600
800
1000
1200
1278 a.a.

Protein Preferred Names	Protein Names
papilin

PAPLN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83874	PAPLN Antibody (YA3571)	WB, ICC/IF, ELISA	Human, Mouse
HY-P83874A	PAPLN Antibody (YA3571)(PBS only)	WB, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Radial Nerve Lesion	Lesion Of Radial Nerve Radial Nerve Lesions Radial Neuropathy Radial Nerve Mononeuritis
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Ehlers-Danlos Syndrome, Dermatosparaxis Type	Dermatosparaxis EDSDERMS Ehlers-Danlos Syndrome, Type Vii, Autosomal Recessive Eds Viic Eds7c Ehlers-Danlos Syndrome Dermatosparaxis Type Dermatosparaxis Ehlers-Danlos Syndrome Dermatosparaxis Eds Ehlers-Danlos Syndrome Type 7c Deds Human Dermatosparaxis Eds Viic Ehlers-Danlos Syndrome 7c Ehlers-Danlos Syndrome, Type Viic
Radial Neuropathy
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Isolated Ectopia Lentis	Familial Ectopia Lentis Ectopia Lentis Ectopia Lentis Syndrome Lens Subluxation Iel Congenital Ectopia Lentis Subluxation Of Lens Ectopia Lentis, Isolated Ectopia Lentis Isolated
Acromicric Dysplasia	ACMICD Acromicric Skeletal Dysplasia Dysplasia, Acromicric
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome
Intellectual Developmental Disorder, X-Linked 109	Fraxe Syndrome Fragile Xe Syndrome Mental Retardation, X-Linked, Fraxe Type XLID109 Mrx109 Mental Retardation, X-Linked, Associated With Fragile Site Fraxe Fraxe Mental Retardation Syndrome X-Linked Intellectual Developmental Disorder 109 Fraxe Intellectual Disability Fraxe Mental Retardation, X-Linked 109 Fragile Site On Chromosome Xq28 Fragile Site, Folic Acid Type X-Linked Intellectual Disability Associated With Fragile Site Fraxe Fraxe Intellectual Deficit Intellectual Disability Associated With Fragile Site Fraxe
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10025	PAPLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PAPLN	VGNC	VGNC:49735
Mus musculus	PAPLN	MGD	MGI:2386139
Rattus norvegicus	PAPLN	RGD	RGD:1311176
Felis catus	PAPLN	VGNC	VGNC:64034
Macaca mulatta	PAPLN	VGNC	VGNC:75647
Bos taurus	PAPLN	VGNC	VGNC:32571
Others	PAPLN	NCBI