LACRT - lacritin Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90070

About LACRT

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,630,811-54,634,895 (from NCBI)

This gene has 4 transcripts (splice variants), 18 orthologues and 1 paralogue. Restricted expression toward salivary gland (RPKM 2.0).

Summary

The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

LACRT Products (1)

mRNA Protein Name
NM_033277.2 NP_150593.1 extracellular glycoprotein lacritin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
11419941 GOA
enables growth factor activity IDA
IDA: Inferred from direct assay
16982797 GOA
enables laminin-1 binding IDA
IDA: Inferred from direct assay
11419941 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11419941 GOA
Biological Process GO Annotation Evidence References Source
involved in calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
16923831 GOA
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
11419941 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
24942736 GOA
involved in epithelial structure maintenance IDA
IDA: Inferred from direct assay
25034600 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
26670139 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
26670139 GOA
involved in positive regulation of calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
16923831 GOA
involved in positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
25530855 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11419941 GOA
involved in positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
16923831 GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing IDA
IDA: Inferred from direct assay
25530855 GOA
involved in positive regulation of macroautophagy IDA
IDA: Inferred from direct assay
23640897 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11419941 GOA
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
16923831 GOA
involved in positive regulation of secretion IDA
IDA: Inferred from direct assay
11419941 GOA
involved in protein localization to Golgi apparatus IDA
IDA: Inferred from direct assay
16923831 GOA
involved in tear secretion IDA
IDA: Inferred from direct assay
25034600 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
17850790 GOA
located in secretory granule IDA
IDA: Inferred from direct assay
11419941 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

extracellular glycoprotein lacritin

Recombinant LACRT Proteins

Cat. No. Product Name Accession Purity
HY-P70911 Lacritin Protein, Human (His) Q9GZZ8 (A19-A138) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Blepharitis
Chronic Follicular Conjunctivitis
Apperceptive Agnosia
Lacrimal Apparatus Disease

  • Lacrimal Apparatus Diseases
Eyelid Disease

  • Eyelid Diseases

  • Eyelid Disorders
Cicatricial Entropion
Keratopathy
Dry Eye Syndrome

  • Dry Eye Syndromes

  • Dry Eye Disease

  • Tear Film Insufficiency

  • Xerophthalmia
Conjunctivochalasis
Filamentary Keratitis
Orbital Cellulitis

  • Cellulitis Of Orbit
Acute Orbital Inflammation

  • Acute Inflammation Of Orbit
Papillary Conjunctivitis
Accommodative Spasm

  • Spasm Of Accommodation

  • Cyclospasm

  • Ciliary Muscle Spasm

  • Ciliary Body Spasm
Giant Papillary Conjunctivitis

  • Gpc

  • Conjunctivitis Giant Papillary

  • Conjunctivitis, Giant Papillary

  • Chronic Giant Papillary Conjunctivitis

  • Chronic Papillary Conjunctivitis
Exposure Keratitis

  • Exposure Keratoconjunctivitis

  • Lagophthalmic Keratitis
Entropion
Punctate Epithelial Keratoconjunctivitis

  • Punctate Keratitis

  • Thygeson Superficial Punctate Keratitis

  • Thygeson'S Superficial Punctate Keratitis

  • Thygeson Superficial Punctate Keratopathy

  • Punctate Epithelial Keratitis
Excessive Tearing

  • Epiphora

  • Lacrimal Apparatus Diseases

  • Excessive Tear Production

  • Watering Eye
Corneal Disease

  • Corneal Diseases

  • Corneal Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07488 LACRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown