IGSF8 - immunoglobulin superfamily member 8 Gene

Also Known as EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93185

About IGSF8

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,091,339-160,099,468 (from NCBI)

This gene has 5 transcripts (splice variants), 170 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 17.6), skin (RPKM 9.6) and 24 other tissues.

Summary

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral Infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

IGSF8 Products (3)

mRNA Protein Name
NM_001206665.2 NP_001193594.1 immunoglobulin superfamily member 8 precursor
NM_001320247.2 NP_001307176.1 immunoglobulin superfamily member 8 precursor
NM_052868.6 NP_443100.1 immunoglobulin superfamily member 8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11504738 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
17785435 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
17785435 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11504738 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGSF8 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (36 - 141)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 613 a.a.
Protein Preferred Names Protein Names

immunoglobulin superfamily member 8

  • CD81 partner 3

IGSF8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
IGSF8 Q969P0 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
IGSF8 Q969P0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
IGSF8 Q969P0 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
IGSF8 Q969P0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
IGSF8 Q969P0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
IGSF8 Q969P0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
IGSF8 Q969P0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
IGSF8 Q969P0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
IGSF8 Q969P0 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
IGSF8 Q969P0 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
IGSF8 Q969P0 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
IGSF8 Q969P0 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
IGSF8 Q969P0 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
IGSF8 Q969P0 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
IGSF8 Q969P0 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGSF8 Proteins

Cat. No. Product Name Accession Purity
HY-P72736 CD316/IGSF8 Protein, Human (HEK293, His) Q969P0-1 (R28-T579) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Atrial Septal Defect 2

  • ASD2

  • Atrial Heart Septal Defect 2

  • Atrial Septal Defect-2

  • Asd Ii

  • Septal Defect, Atrial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06651 IGSF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19693 Igsf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26188 Igsf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IGSF8 RGD RGD:1311500
Mus musculus IGSF8 MGD MGI:2154090
Canis familiaris IGSF8 VGNC VGNC:41918
Bos taurus IGSF8 VGNC VGNC:30096
Felis catus IGSF8 VGNC VGNC:62897
Macaca mulatta IGSF8 VGNC VGNC:73615
Others IGSF8 NCBI