EXOG - exo/endonuclease G Gene

Homo sapiens

Also known as ENGL; ENGLA; ENGLB; ENGL-a; ENGL-b; ENDOGL1; ENDOGL2

Gene ID: 9941 | Gene type: protein coding

About EXOG

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,496,340-38,526,303 (from NCBI)

This gene has 17 transcripts (splice variants), 157 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 2.2), lymph node (RPKM 1.6) and 25 other tissues.

Summary

This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded Enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This Enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

EXOG Products(2)

mRNA	Protein	Name
NM_001145464.2	NP_001138936.1	nuclease EXOG, mitochondrial isoform 2 precursor
NM_005107.4	NP_005098.2	nuclease EXOG, mitochondrial isoform 1 precursor

EXOG Protein Structure

Endonuclease_NS

0
100
200
300
368 a.a.

Protein Preferred Names

Protein Names

nuclease EXOG, mitochondrial

endo G-like 1

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04595	EXOG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EXOG	VGNC	VGNC:40520
Felis catus	EXOG	VGNC	VGNC:62006
Rattus norvegicus	EXOG	RGD	RGD:1304628
Bos taurus	EXOG	VGNC	VGNC:28654
Mus musculus	EXOG	MGD	MGI:2143333
Macaca mulatta	EXOG	VGNC	VGNC:72419