EXOG - exo/endonuclease G Gene

Also Known as ENGL; ENGLA; ENGLB; ENGL-a; ENGL-b; ENDOGL1; ENDOGL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9941

About EXOG

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,496,340-38,526,303 (from NCBI)

This gene has 17 transcripts (splice variants), 157 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 2.2), lymph node (RPKM 1.6) and 25 other tissues.

Summary

This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

EXOG Products (2)

mRNA Protein Name
NM_001145464.2 NP_001138936.1 nuclease EXOG, mitochondrial isoform 2 precursor
NM_005107.4 NP_005098.2 nuclease EXOG, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-3' exonuclease activity IDA
IDA: Inferred from direct assay
18187503 GOA
enables endonuclease activity IDA
IDA: Inferred from direct assay
18187503 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
18187503 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
25378300 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOG Protein Structure

Endonuclease_NS

Endonuclease_NS: DNA/RNA non-specific endonuclease (77 - 286)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

nuclease EXOG, mitochondrial

  • endo G-like 1

EXOG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXOG Q9Y2C4 ZER1 Homo sapiens Q7Z7L7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

EXOG Antibodies

Cat. No. Product Name Application Reactivity
HY-P81940 ENDOGL1 Antibody (YA1685) WB Human
HY-P81940A ENDOGL1 Antibody (YA1685)(PBS only) WB Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04595 EXOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EXOG VGNC VGNC:40520
Felis catus EXOG VGNC VGNC:62006
Rattus norvegicus EXOG RGD RGD:1304628
Bos taurus EXOG VGNC VGNC:28654
Mus musculus EXOG MGD MGI:2143333
Macaca mulatta EXOG VGNC VGNC:72419
Others EXOG NCBI