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GOLGA5 - golgin A5 Gene

Also Known as RFG5; GOLIM5; ret-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9950

About GOLGA5

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,794,305-92,839,947 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 69 phenotypes. Ubiquitous expression in testis (RPKM 23.6), thyroid (RPKM 21.8) and 25 other tissues.

Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during Mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the RET proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

GOLGA5 Products (1)

mRNA	Protein	Name
NM_005113.4	NP_005104.4	golgin subfamily A member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9915833	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	12538640	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	12538640	GOA
involved in Golgi vesicle transport	IMP IMP: Inferred from mutant phenotype	12538640	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	9915833	GOA
located in Golgi cisterna	IDA IDA: Inferred from direct assay	12538640	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	12538640	GOA
located in membrane	IDA IDA: Inferred from direct assay	9915833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOLGA5 Protein Structure

Golgin_A5

0
200
400
600
731 a.a.

Protein Preferred Names	Protein Names
golgin subfamily A member 5	RET-fused gene 5 protein

Related Diseases

Diseases	Alias
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Congenital Disorder Of Glycosylation, Type Iig	CDG2G Congenital Disorder Of Glycosylation Type Iig Cdg Iig Cdgiig Cdgii/Cog1 Cerebrocostomandibular-Like Syndrome Carbohydrate Deficient Glycoprotein Syndrome Type Iig Cdg-Iig Congenital Disorder Of Glycosylation, Type 2g Cog1-Cdg Cdg Syndrome Type Iig Congenital Disorder Of Glycosylation Type 2g Congenital Disorder Of Glycosylation 2g Cdg-Ii Caused By Cog1 Deficiency Glycosylation, Congenital Disorder Of, Type Iig
Chlamydia	Chlamydial Infection Chlamydia Trachomatis Infectious Disease Chlamydial Disease Chlamydia Infections
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05586	GOLGA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GOLGA5	VGNC	VGNC:41341
Macaca mulatta	GOLGA5	VGNC	VGNC:73108
Rattus norvegicus	GOLGA5	RGD	RGD:1308163
Felis catus	GOLGA5	VGNC	VGNC:62640
Bos taurus	GOLGA5	VGNC	VGNC:29486
Mus musculus	GOLGA5	MGD	MGI:1351475
Others	GOLGA5	NCBI