GLP-1R prodrug-1
GLP-1R prodrug-1 is a GLP-1R agonist prodrug. GLP-1R prodrug-1 lacks direct GLP-1R agonistic activity. GLP-1R prodrug-1 is slowly converted into its active free acid metabolite GLP-1R agonist 45 (HY-187343) in plasma via esterase-mediated hydrolysis. GLP-1R prodrug-1 can be used in the research of type 2 diabetes and obesity.
For research use only. We do not sell to patients.
- Formula: C32H32FN5O4
- Molecular Weight:569.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GLP-1 |
GLP-1R prodrug-1 (Compound 4) (1 μM; 15 min) shows no activity against GLP-1R in HEK293 cells, while its active metabolite GLP-1R agonist 45 (HY-187343) fully activates GLP-1R with an EC50 of 2.20 nM[1].
GLP-1R prodrug-1 (0.1-1 μM; 1-168 h) undergoes slow, controlled conversion to its active metabolite Compound 4a in pooled plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 569.63
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Formula C32H32FN5O4
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SMILES
O=C(C1=CC=C2C(N(C[C@H]3OCC3)C(CN4CCN(C5=CC=CC(OCC6=CC=C(C#N)C=C6F)=C5)CC4)=N2)=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GLP-1R prodrug-1 Related Classifications
HY-187344 Related Classifications
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