2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK
  3. HDAC VEGFR
  4. HDAC-IN-35

HDAC-IN-35 (Compound 14) is a potent, selective HDAC and VEGFR-2 inhibitor, with IC50 values of 0.166 and 13.2 µM for HDAC6 and VEGFR-2, respectively.

For research use only. We do not sell to patients.

HDAC-IN-35

HDAC-IN-35 Chemical Structure

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HDAC-IN-35 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

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Description

HDAC-IN-35 (Compound 14) is a potent, selective HDAC and VEGFR-2 inhibitor, with IC50 values of 0.166 and 13.2 µM for HDAC6 and VEGFR-2, respectively[1].

IC50 & Target

HDAC6

0.166 μM (IC50)

HDAC8

1.99 μM (IC50)

HDAC1

7.23 μM (IC50)

VEGFR2

13.2 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
3.4 μM
Compound: 14
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 34634618]
PC-3 IC50
1.9 μM
Compound: 14
Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 34634618]
SK-HEP1 IC50
3.2 μM
Compound: 14
Anticancer activity against human SK-HEP1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human SK-HEP1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 34634618]
In Vitro

HDAC-IN-35 (Compound 14) (0-10 µM, 48 h) shows anticancer effects in different cancer cells[1].
HDAC-IN-35 (0-10 µM, 48 h) exhibits potent anti-angiogenic activity with a GI>50 (50% growth inhibition) value of 1.0 μM on human endothelial progenitor cells (EPCs) through a VEGFR-2-dependent pathway, without obvious systemic toxicity[1].
HDAC-IN-35 exhibits moderate VEGFR-2 inhibitory activities and displays the anticancer effects by inhibiting the enzymatic activity of HDAC[1].
HDAC-IN-35 (0-10 µM, 24 h) concentration-dependently impedes the capillary-like tube formation in human EPCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-35 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, PC-3, and SK-Hep-1
Concentration: 0-10 µM
Incubation Time: 48 h
Result: Showed anticancer effects with IC50 values of 3.4, 1.9 and 3.2 µM against A549, PC-3, and SK-Hep-1 cells.

Western Blot Analysis[1]

Cell Line: A549, PC-3, and SK-Hep-1, and human EPCs
Concentration: 0, 5, and 10 µM
Incubation Time: 24 h
Result: Increased the amount of acetylated α-tubulin and histone H3 in a concentration-dependent manner in cancer cells. Induced mild inhibition of the phosphorylation of VEGFR-2 in human EPCs.
Molecular Weight

399.75

Formula

C17H13ClF3N3O3
SMILES

O=C(NO)/C=C/C1=CC=C(C=C1)NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-35HDACVEGFRHistone deacetylasesVascular endothelial growth factor receptorA549PC-3SK-Hep-1EPCsInhibitorinhibitorinhibit

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