Heparin disaccharide I-H trisodium
Heparin disaccharide I-H trisodium (Compound SHS-5) is a heparin-derived disaccharide. Heparin disaccharide I-H trisodium blocks the spontaneous secretion of IL-8 and IL-1β in intestinal epithelial cells at the post-translational stage without reducing mRNA expression levels or intracellular contents. Heparin disaccharide I-H trisodium exhibits dose-dependent anti-inflammatory activity in intestinal epithelial cell models.
For research use only. We do not sell to patients.
- CAS No.: 136098-04-9
- Formula: C12H16NNa3O16S2
- Molecular Weight:563.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IL-8 |
IL-1β |
In Vitro
Heparin disaccharide I-H (0.01-100 ng/mL; 24 h) dose-dependently inhibits the spontaneous secretion of IL-8 and IL-1β in HT-29 intestinal epithelial cells, with significant inhibitory effects observed starting at the concentration of 0.01 ng/mL[1].
Heparin disaccharide I-H (0.01-100 ng/mL; 24 h) dose-dependently inhibits the spontaneous secretion of IL-8 and IL-1β by Caco-2 intestinal epithelial cells, and exerts a significant inhibitory effect starting at the concentration of 0.1 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 intestinal epithelial cells
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Concentration:0.01-100 ng/mL
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Incubation Time:24 h
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Result:Dose-dependently inhibited spontaneous IL-8 secretion, with significant reduction (P < 0.001) at concentrations ≥0.01 ng/mL.
Dose-dependently inhibited spontaneous IL-1β secretion, with significant reduction (P < 0.001) at concentrations ≥0.01 ng/mL.
Showed varying inhibition intensity relative to other active disaccharides at low concentrations, indicating structure-dependent affinity for cellular targets.
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Cell Line:Caco-2 intestinal epithelial cells
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Concentration:0.01-100 ng/mL
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Incubation Time:24 h
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Result:Dose-dependently inhibited spontaneous IL-8 secretion, with significant reduction (P < 0.001) at concentrations ≥0.1 ng/mL.
Dose-dependently inhibited spontaneous IL-1β secretion, with significant reduction (P < 0.001) at concentrations ≥0.1 ng/mL.
Exhibited a general response pattern matching HT-29 cells, with minor differences in inhibitory kinetics.
Chemical Information
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CAS No. 136098-04-9
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Molecular Weight 563.35
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Formula C12H16NNa3O16S2
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SMILES
O=S(OC[C@@H](O)[C@H]([C@H](O)[C@@H](N)C=O)O[C@H]1[C@@H]([C@H](C=C(O1)C(O[Na])=O)O)OS(=O)(O[Na])=O)(O[Na])=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heparin disaccharide I-H trisodium Related Classifications
HY-N18953 Related Classifications
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