2. Immunology/Inflammation
  3. Interleukin Related
  4. Heparin disaccharide I-H trisodium

Heparin disaccharide I-H trisodium (Compound SHS-5) is a heparin-derived disaccharide. Heparin disaccharide I-H trisodium blocks the spontaneous secretion of IL-8 and IL-1β in intestinal epithelial cells at the post-translational stage without reducing mRNA expression levels or intracellular contents. Heparin disaccharide I-H trisodium exhibits dose-dependent anti-inflammatory activity in intestinal epithelial cell models.

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Heparin disaccharide I-H trisodium

Heparin disaccharide I-H trisodium Chemical Structure

CAS No. : 136098-04-9

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Heparin disaccharide I-H trisodium Related Antibodies

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Description

Heparin disaccharide I-H trisodium (Compound SHS-5) is a heparin-derived disaccharide. Heparin disaccharide I-H trisodium blocks the spontaneous secretion of IL-8 and IL-1β in intestinal epithelial cells at the post-translational stage without reducing mRNA expression levels or intracellular contents. Heparin disaccharide I-H trisodium exhibits dose-dependent anti-inflammatory activity in intestinal epithelial cell models[1].

IC50 & Target[1]

IL-8

 

IL-1β

 

In Vitro

Heparin disaccharide I-H (0.01-100 ng/mL; 24 h) dose-dependently inhibits the spontaneous secretion of IL-8 and IL-1β in HT-29 intestinal epithelial cells, with significant inhibitory effects observed starting at the concentration of 0.01 ng/mL[1].
Heparin disaccharide I-H (0.01-100 ng/mL; 24 h) dose-dependently inhibits the spontaneous secretion of IL-8 and IL-1β by Caco-2 intestinal epithelial cells, and exerts a significant inhibitory effect starting at the concentration of 0.1 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Heparin disaccharide I-H trisodium Related Antibodies

ELISA Assay[1]

Cell Line: HT-29 intestinal epithelial cells
Concentration: 0.01-100 ng/mL
Incubation Time: 24 h
Result: Dose-dependently inhibited spontaneous IL-8 secretion, with significant reduction (P < 0.001) at concentrations ≥0.01 ng/mL.
Dose-dependently inhibited spontaneous IL-1β secretion, with significant reduction (P < 0.001) at concentrations ≥0.01 ng/mL.
Showed varying inhibition intensity relative to other active disaccharides at low concentrations, indicating structure-dependent affinity for cellular targets.

ELISA Assay[1]

Cell Line: Caco-2 intestinal epithelial cells
Concentration: 0.01-100 ng/mL
Incubation Time: 24 h
Result: Dose-dependently inhibited spontaneous IL-8 secretion, with significant reduction (P < 0.001) at concentrations ≥0.1 ng/mL.
Dose-dependently inhibited spontaneous IL-1β secretion, with significant reduction (P < 0.001) at concentrations ≥0.1 ng/mL.
Exhibited a general response pattern matching HT-29 cells, with minor differences in inhibitory kinetics.
Molecular Weight

563.35

Formula

C12H16NNa3O16S2
CAS No.
SMILES

O=S(OC[C@@H](O)[C@H]([C@H](O)[C@@H](N)C=O)O[C@H]1[C@@H]([C@H](C=C(O1)C(O[Na])=O)O)OS(=O)(O[Na])=O)(O[Na])=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Heparin disaccharide I-H trisodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Heparin disaccharide I-H trisodium136098-04-9Interleukin RelatedILintestinal epithelial cellsHT-29iduronic acidanti-inflammatory activityIL-8glucosamineTNF-αCaco-2IL-1βInhibitorinhibitorinhibit

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