1. Anti-infection
  2. HIV
  3. HIV-1 inhibitor-13

HIV-1 inhibitor-13 

Cat. No.: HY-144112
Handling Instructions

HIV-1 inhibitor-13 (compound 16c) is a orally active and potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50 of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of HIV-1 resistant strains, with EC50 values of 2.85-18.0 nM.

For research use only. We do not sell to patients.

HIV-1 inhibitor-13 Chemical Structure

HIV-1 inhibitor-13 Chemical Structure

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Description

HIV-1 inhibitor-13 (compound 16c) is a orally active and potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50 of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of HIV-1 resistant strains, with EC50 values of 2.85-18.0 nM[1].

IC50 & Target

HIV-1 (WT)

2.85 ± 1.1 nM (EC50)

In Vivo

HIV-1 inhibitor-13 (compound 16c) (SD rats; 2 mg/kg, IV; 10 mg/kg, PO; once) exhibits favorable pharmacokinetic profiles (F = 32.1% and T1/2 = 0.88 and 1.05 h, respectively)[1].
HIV-1 inhibitor-13 (Kunming mice, 2000 mg/kg, PO, once) shows safety in Kunming mice (LD50 > 2000 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

524.61

Formula

C30H32N6O3

SMILES

CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C3COCC3=NC(NC4CCN(CC4)CC5=CC=C(C=C5)C(N)=O)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
HIV-1 inhibitor-13
Cat. No.:
HY-144112
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