HIV-1 inhibitor-13
HIV-1 inhibitor-13 (compound 16c) is a orally active and potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50 of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of HIV-1 resistant strains, with EC50 values of 2.85-18.0 nM.
For research use only. We do not sell to patients.
- CAS No.: 2761172-60-3
- Formula: C30H32N6O3
- Molecular Weight:524.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 2.85 ± 1.1 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| MT4 | CC50 |
24.1 μM
Compound: 16c
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 35061384] |
HIV-1 inhibitor-13 (Kunming mice, 2000 mg/kg, PO, once) shows safety in Kunming mice (LD50 > 2000 mg/kg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2761172-60-3
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Molecular Weight 524.61
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Formula C30H32N6O3
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SMILES
CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C3COCC3=NC(NC4CCN(CC4)CC5=CC=C(C=C5)C(N)=O)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-13 Related Classifications
HY-144112 Related Classifications
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