HIV-1 inhibitor-41
HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity.
For research use only. We do not sell to patients.
- CAS No.: 3033425-97-4
- Formula: C16H15F2N3OS
- Molecular Weight:335.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 20.8 nM (IC50) |
HIV-1 (E138K) 50 nM (IC50) |
HIV-1 (Y181C) 0.75 μM (IC50) |
HIV-1 (L100I) 1.03 μM (IC50) |
HIV-1 (K103N) 3.39 μM (IC50) |
HIV-1 (Y188L) 69.04 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
136.68 μM
Compound: B23
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Cytotoxicity against human MT4 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 35679690] |
Chemical Information
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CAS No. 3033425-97-4
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Molecular Weight 335.37
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Formula C16H15F2N3OS
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SMILES
CC1=C(N=C(NC1=O)SC(C)C)C(C2=C(C=CC=C2F)F)C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-41 Related Classifications
HY-147841 Related Classifications
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