2. Anti-infection
  3. HPV
  4. Human Papillomavirus (HPV) E7 protein (49-57)

Human Papillomavirus (HPV) E7 protein (49-57) 

Cat. No.: HY-P1907 Purity: 98.30%
COA
SDS
Handling Instructions Technical Support

Human Papillomavirus (HPV) E7 protein (49-57) is a cytotoxic T lymphocyte (CTL) epitope peptide derived from HPV16 E7 protein (sequence: RAHYNIVTF). Human Papillomavirus (HPV) E7 protein (49-57) induces E749-57-specific CTL responses. Human Papillomavirus (HPV) E7 protein (49-57) can be used for the research of cervical cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Human Papillomavirus (HPV) E7 protein (49-57)

Human Papillomavirus (HPV) E7 protein (49-57) Chemical Structure

CAS No. : 151812-18-9

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Human Papillomavirus (HPV) E7 protein (49-57) Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Human Papillomavirus (HPV) E7 protein (49-57) is a cytotoxic T lymphocyte (CTL) epitope peptide derived from HPV16 E7 protein (sequence: RAHYNIVTF). Human Papillomavirus (HPV) E7 protein (49-57) induces E749-57-specific CTL responses. Human Papillomavirus (HPV) E7 protein (49-57) can be used for the research of cervical cancer[1].

In Vitro

Human Papillomavirus (HPV) E7 protein (49-57) (100 μg/mL; 5 days) promotes the growth of red blood cell-free splenocytes of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Human Papillomavirus (HPV) E7 protein (49-57) Related Antibodies

Cell Proliferation Assay[1]

Cell Line: red blood cell-free splenocytes of mice
Concentration: 100 μg/mL
Incubation Time: 5 days
Result: Promoted the growth of the cell.
In Vivo

The Human Papillomavirus (HPV) E7 protein (49-57) (50 μg; i.p.; on days 5, 9, and 14) demonstrates potent anti-tumor efficacy in a mouse cervical cancer model, with the strongest effects observed when formulated as an ORP150-E749-57 complex plus Poly(I:C) (HY-107202), resulting in 90% survival at day 70 and a mean tumor volume of ~400 mm3 by day 33[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (6- to 8-week-old female; subcutaneous injection of 5×105 TC-1 cells)[1]
Dosage: 50 μg; 50 μg (admixed with poly(I:C))
Administration: i.p.; on days 5, 9, and 14
Result: Showed no significant in vivo anti-tumor efficacy, with tumor growth and survival similar to control groups (standalone treatment).
Inhibited tumor growth, with mean tumor volume reaching ~3500 mm3 by day 33, and significantly prolonged survival compared to control groups (admixed with poly(I:C)).
Molecular Weight

1120.26

Formula

C52H77N15O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Ala-His-Tyr-Asn-Ile-Val-Thr-Phe
Sequence Shortening

RAHYNIVTF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (22.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8926 mL 4.4632 mL 8.9265 mL
5 mM 0.1785 mL 0.8926 mL 1.7853 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8926 mL 4.4632 mL 8.9265 mL 22.3162 mL
5 mM 0.1785 mL 0.8926 mL 1.7853 mL 4.4632 mL
10 mM 0.0893 mL 0.4463 mL 0.8926 mL 2.2316 mL
15 mM 0.0595 mL 0.2975 mL 0.5951 mL 1.4877 mL
20 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1158 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Human Papillomavirus (HPV) E7 protein (49-57) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Human Papillomavirus (HPV) E7 protein (49-57)151812-18-9HPVHuman papillomavirusTC-1 tumor-bearing micemouse cervical cancer modelrecombinant mouse ORP150splenocytescervical cancerORP150poly(I:C)HPV16 E7 proteincytotoxic T lymphocyteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Human Papillomavirus (HPV) E7 protein (49-57)
Cat. No.:
HY-P1907
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.