Bethoxazin
Based on 1 Customer Validation
Bethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae.
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 163269-30-5
- Formula: C11H9NO2S2
- Molecular Weight:251.32
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Topoisomerase Isoforms
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Biological Activity
Bethoxazin (30-100 μM) is highly reactive toward free sulfhydryl groups (GSH, cysteine, HSA) but does not react with amino, carboxylic, phenolic, amino oxo, alcoholic, or phosphate functional groups under tested conditions[1].
Bethoxazin (100 μM; 8 h) undergoes nucleophilic attack at C3 of its oxathiazine oxide ring by sulfhydryl groups, forming ring-opened intermediates that react with a second sulfhydryl molecule to produce disulfide adducts[1].
Bethoxazin (66 μM; 5 h) forms a covalent adduct with free human serum albumin at an equimolar ratio, reacting with the single free cysteine residue of HSA[1].
Bethoxazin (0.01-100 μM; 6 h) potently inhibits the growth of yeast BY4742 cells with an IC50 of 11 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:yeast BY4742 strain
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Concentration:0.01, 0.1, 1, 10 and 100 μM
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Incubation Time:6 h
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Result:Inhibited yeast cell growth in a concentration-dependent manner, with an IC50 of 11 μM.
Chemical Information
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CAS No. 163269-30-5
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Appearance Solid
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Molecular Weight 251.32
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Formula C11H9NO2S2
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Color Light yellow to light brown
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SMILES
O=S1C(C2=CC3=CC=CC=C3S2)=NOCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (99.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (949 KB)
- English - EN (949 KB)
- Français - FR (949 KB)
- Deutsch - DE (949 KB)
- Norwegian - NO (949 KB)
- Español - ES (949 KB)
- Swedish - SV (949 KB)
- Italian - IT (949 KB)
- Korean - KR (949 KB)
- Portuguese - PT (949 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9790 mL | 19.8950 mL | 39.7899 mL | 99.4748 mL |
| 5 mM | 0.7958 mL | 3.9790 mL | 7.9580 mL | 19.8950 mL | |
| 10 mM | 0.3979 mL | 1.9895 mL | 3.9790 mL | 9.9475 mL | |
| 15 mM | 0.2653 mL | 1.3263 mL | 2.6527 mL | 6.6317 mL | |
| 20 mM | 0.1989 mL | 0.9947 mL | 1.9895 mL | 4.9737 mL | |
| 25 mM | 0.1592 mL | 0.7958 mL | 1.5916 mL | 3.9790 mL | |
| 30 mM | 0.1326 mL | 0.6632 mL | 1.3263 mL | 3.3158 mL | |
| 40 mM | 0.0995 mL | 0.4974 mL | 0.9947 mL | 2.4869 mL | |
| 50 mM | 0.0796 mL | 0.3979 mL | 0.7958 mL | 1.9895 mL | |
| 60 mM | 0.0663 mL | 0.3316 mL | 0.6632 mL | 1.6579 mL | |
| 80 mM | 0.0497 mL | 0.2487 mL | 0.4974 mL | 1.2434 mL |
Bethoxazin Related Classifications
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