CADPS - calcium dependent secretion activator Gene

Also Known as CAPS; CAPS1; CADPS1; UNC-31

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8618

About CADPS

Cytogenetic location: 3p14.2 Genomic coordinates (GRCh38): 3:62,398,348-62,875,416 (from NCBI)

This gene has 20 transcripts (splice variants) and 28 orthologues. Biased expression in brain (RPKM 14.7), adrenal (RPKM 5.4) and 9 other tissues.

Summary

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

CADPS Products (3)

mRNA Protein Name
NM_003716.4 NP_003707.2 calcium-dependent secretion activator 1 isoform 1
NM_183393.3 NP_899630.1 calcium-dependent secretion activator 1 isoform 3
NM_183394.3 NP_899631.1 calcium-dependent secretion activator 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17984325 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CADPS Protein Structure

DUF1041

DUF1041: Domain of Unknown Function (DUF1041) (835 - 940)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1353 a.a.
Protein Preferred Names Protein Names

calcium-dependent secretion activator 1

  • CAPS-1

Related Diseases

Diseases Alias
Jejunal Somatostatinoma

  • Jejunal Delta Cell Somatostatin Producing Tumor

  • Somatosatinoma Of Jejunum

  • Jejunal Somatostatin-Producing Neuroendocrine Tumor
Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

  • Pediatric Cns Pnet

  • Childhood Central Nervous System Primitive Neuroectodermal Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01823 CADPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01824 CADPS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CADPS VGNC VGNC:26698
Felis catus CADPS VGNC VGNC:80014
Canis familiaris CADPS VGNC VGNC:38658
Rattus norvegicus CADPS RGD RGD:708573
Mus musculus CADPS MGD MGI:1350922
Others CADPS NCBI