KYNU - kynureninase Gene

Also Known as KYNUU; VCRL2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8942

About KYNU

Cytogenetic location: 2q22.2 Genomic coordinates (GRCh38): 2:142,877,664-143,055,833 (from NCBI)

This gene has 9 transcripts (splice variants), 224 orthologues and is associated with 4 phenotypes. Broad expression in liver (RPKM 2.5), urinary bladder (RPKM 1.8) and 14 other tissues.

Summary

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

KYNU Products (3)

mRNA	Protein	Name
NM_001032998.2	NP_001028170.1	kynureninase isoform b
NM_001199241.2	NP_001186170.1	kynureninase isoform a
NM_003937.3	NP_003928.1	kynureninase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kynureninase activity	IDA IDA: Inferred from direct assay	9180257	GOA
enables kynureninase activity	IMP IMP: Inferred from mutant phenotype	17334708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11985583	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NAD biosynthetic process	IMP IMP: Inferred from mutant phenotype	28792876	GOA
involved in anthranilate metabolic process	IDA IDA: Inferred from direct assay	11985583	GOA
involved in quinolinate biosynthetic process	IDA IDA: Inferred from direct assay	9291104	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	9291104	GOA
involved in response to vitamin B6	IMP IMP: Inferred from mutant phenotype	1939450	GOA
involved in tryptophan catabolic process	IMP IMP: Inferred from mutant phenotype	17334708	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	6468727	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	6468727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KYNU Protein Structure

Aminotran_5

0
100
200
300
400
465 a.a.

Protein Preferred Names	Protein Names
kynureninase

Recombinant KYNU Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75903	KYNU/Kynureninase Protein, Human (sf9, His)	Q16719 (M1-N465)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hydroxykynureninuria	Xanthurenic Aciduria Kynureninase Deficiency Kynureninase Deficiency, Partial HYXKY Partial Kynureninase Deficiency
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2	VCRL2 Congenital Nad Deficiency Disorder 2 Kynureninase Deficiency, Complete
Congenital Vertebral-Cardiac-Renal Anomalies Syndrome	Congenital Nad Deficiency Disorder
Catel-Manzke Syndrome	Hyperphalangy-Clinodactyly Of Index Finger With Pierre Robin Syndrome Micrognathia Digital Syndrome Pierre Robin Syndrome With Hyperphalangy And Clinodactyly Index Finger Anomaly With Pierre Robin Syndrome Palatodigital Syndrome, Catel-Manzke Type Catel Manzke Syndrome CATMANS Palatodigital Syndrome Catel-Manzke Type Index Finger Anomaly-Pierre Robin Syndrome Pierre Robin Sequence-Hyperphalangy-Clinodactyly Syndrome Pierre Robin Syndrome-Hyperphalangy-Clinodactyly Syndrome
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Pellagra	Niacin Deficiency Niacin-Tryptophan Deficiency Pellagroid Syndrome
Meier-Gorlin Syndrome 2	MGORS2 Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9	Epilepsy, Idiopathic Generalized, Susceptibility To, 9 EIG9 Epilepsy, Juvenile Myoclonic 6 Idiopathic Generalized Epilepsy 9 Epilepsy, Juvenile Myoclonic, Susceptibility To, 6 Susceptibility To Idiopathic Generalized Epilepsy 9 Juvenile Myoclonic Epilepsy 6 EJM6 Susceptibility To Juvenile Myoclonic Epilepsy 6 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17219	Kynu Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07480	KYNU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23671	Kynu Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KYNU	VGNC	VGNC:30759
Felis catus	KYNU	VGNC	VGNC:67998
Mus musculus	KYNU	MGD	MGI:1918039
Rattus norvegicus	KYNU	RGD	RGD:71061
Canis familiaris	KYNU	VGNC	VGNC:42555
Macaca mulatta	KYNU	VGNC	VGNC:74223
Others	KYNU	NCBI