ELOB - elongin B Gene

Also Known as SIII; TCEB2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6923

About ELOB

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,771,414-2,777,280 (from NCBI)

This gene has 8 transcripts (splice variants) and 281 orthologues. Ubiquitous expression in testis (RPKM 67.4), adrenal (RPKM 41.2) and 25 other tissues.

Summary

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

ELOB Products (2)

mRNA Protein Name
NM_007108.4 NP_009039.1 elongin-B isoform a
NM_207013.3 NP_996896.1 elongin-B isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10205047 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
7660122 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
17636018 GOA
Biological Process GO Annotation Evidence References Source
involved in target-directed miRNA degradation IMP
IMP: Inferred from mutant phenotype
33184237 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: Inferred from direct assay
7660122 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17636018 GOA
part of Cul5-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17636018 GOA
part of elongin complex IDA
IDA: Inferred from direct assay
7660122 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOB Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (11 - 64)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

elongin-B

  • RNA polymerase II transcription factor SIII p18 subunit

ELOB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELOB Q15370 MRPL53 Homo sapiens Q96EL3
Validated Y2H
32296183
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
Anti Tag CoIP
12149480
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
X-Ray Diffraction
12050673
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
Y2H Array
25416956
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
X-Ray Diffraction
10205047
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
X-Ray Diffraction
12004076
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
Y2H Prey Pooling
25416956
Intra
ELOB Q15370 ELOC Homo sapiens Q15369
ITC
12004076
Intra
ELOB Q15370 MED8 Homo sapiens Q96G25
Anti Tag CoIP
12149480
Intra
ELOB Q15370 MED8 Homo sapiens Q96G25
Y2H
12149480
Cross
ELOB Q15370 vif Human immunodeficiency virus P12504
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Von Hippel-Lindau Syndrome

  • Von Hippel-Lindau Disease

  • Vhl

  • Vhl Syndrome

  • VHLS

  • Von Hippel-Lindau Syndrome, Modifier Of

  • Hippel Lindau Syndrome

  • Angiomatosis Retinae

  • Cerebelloretinal Angiomatosis, Familial

  • Hippel-Lindau Disease

  • Familial Cerebelloretinal Angiomatosis

  • Lindau Disease

  • VHLD
Molluscum Contagiosum

  • Water Warts

  • Molluscum Verrucosum
Retinal Hemangioblastoma

  • Capillary Hemangioma Of Retina
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Erythrocytosis, Familial, 4

  • ECYT4

  • Familial Erythrocytosis 4

  • Erythrocytosis, Familial, Type 4
Familial Renal Papillary Carcinoma

  • Hereditary Papillary Renal Carcinoma

  • Papillary Renal Cancer Hereditary
Primary Polycythemia

  • Familial Erythrocytosis

  • Familiar Polycythemia

  • Benign Familial Polycythemia

  • Congenital Erythrocytosis

  • Familial Polycythemia

  • Hereditary Erythrocytosis

  • Primary Familial Polycythemia

  • Erythrocytosis, Familial

  • Polycythemia Vera

  • Primary Familial Polycythaemia

  • Primary Inherited Polycythaemia
Erythrocytosis, Familial, 2

  • Chuvash Polycythemia

  • ECYT2

  • Familial Erythrocytosis 2

  • Autosomal Recessive Benign Erythrocytosis

  • Polycythemia, Vhl-Dependent

  • Chuvash Erythromatosis

  • Chuvash Type Polycythemia

  • Chuvash Erythrocytosis

  • Von Hippel-Lindau-Dependent Polycythemia

  • Polycythemia Chuvash Type

  • Vhl-Dependent Polycythemia

  • Erythrocytosis, Familial, Type 2
Kidney Cancer

  • Renal Cancer

  • Renal Carcinoma

  • Kidney Neoplasm

  • Malignant Neoplasm Of Kidney Except Pelvis

  • Malignant Tumour Of Kidney

  • Kidney Neoplasms

  • Cancer, Kidney

  • Cancer, Renal

  • Malignant Neoplasm Of Kidney

  • Renal Cell Carcinoma
Pheochromocytoma

  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant
Hereditary Renal Cell Carcinoma
Cardiovascular Organ Benign Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04318 ELOB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20272 Elob Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26780 Elob Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ELOB RGD RGD:621200
Canis familiaris ELOB VGNC VGNC:40316
Mus musculus ELOB MGD MGI:1914923
Felis catus ELOB VGNC VGNC:80570
Others ELOB NCBI