塩化ベンゼトニウム
Based on 1 publication(s) in Google Scholar
Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes, which has antibacterial, anticancer, antisepsis and disinfection activity. Benzethonium chloride induced Apoptosis and activated caspases in cancer cell lines. Benzethonium chloride ablates the tumor-forming ability of FaDu cells, delays the growth of xenograft tumors in vivo.
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- 純度: 98.47%
- CAS 番号: 121-54-0
- 分子式: C27H42ClNO2
- 分子量:448.08
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Benzethonium chloride
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.2 μM
Compound: BztCl
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 23792315] |
| CCRF-CEM | IC50 |
3.8 μM
Compound: BztCl
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Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay
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[PMID: 23792315] |
| HeLa | IC50 |
5.7 μM
Compound: BztCl
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
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[PMID: 23792315] |
| HUVEC | IC50 |
47 μM
Compound: BztCl
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Cytotoxicity against HUVEC after 72 hrs by MTT assay
Cytotoxicity against HUVEC after 72 hrs by MTT assay
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[PMID: 23792315] |
| MCF7 | IC50 |
5 μM
Compound: BztCl
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Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 23792315] |
| MDA-MB-231 | IC50 |
4.8 μM
Compound: BztCl
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
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[PMID: 23792315] |
| Vero | EC50 |
0.01 μg/mL
Compound: hyamine
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Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
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[PMID: 21546254] |
Benzethonium chloride (0.1 g/L, 10 s) results in only a 50% reduction in bacterial number against S. mutans MT8148 and Streptococcus sobrinus[1].
Benzethonium chloride (0.1-100 μM, 48 h) reduces cell viability against FaDu and C666-1 (both human cancer) cell lines with EC50 values of 3.8 and 5.3 μM, respectively[2].
Benzethonium chloride (9 μM, 24-48 h) induces apoptosis and caspase activation in FaDu cells[2].
Benzethonium chloride (0.1 and 5 mg/L, 24-72 h) shows great acute toxicity to C. elegans, induces an inhibition on hatching and increases mortality in zebrafish embryos[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FaDu cells
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Concentration:9 μM
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Incubation Time:24-48 h
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Result:Revealed nuclear condensation and blebbing and Caspase-2, caspase-8, and caspase-9 activations, indicative of apoptosis, after 48 hours of treatment.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Established xenograft tumors of mice[2]
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Dosage:5 mg/kg
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Administration:i.p., daily for 5 days
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Result:Effectively eliminates the tumorforming potential of FaDu cells and survived for 3.5 days more than PBS-treated mice, which was a statistically significant delay.
化学情報
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CAS 番号 121-54-0
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性状 Solid
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分子量 448.08
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分子式 C27H42ClNO2
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Color White to off-white
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SMILES
CC(C)(C)CC(C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1)(C)C.[Cl-]
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別名
Benzethonium (chloride)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pathol Res Pract
Lactobacillus casei serves as a primary functional strain in fecal microbiota-mediated neuroprotection against cerebral ischemia/reperfusion injury. [Abstract]2026 Jun:282:156441. PMID: 41946028
溶剤 & 溶解度
DMSO : 33.33 mg/mL (74.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (44.63 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 120 mg/mL (267.81 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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参考文献
[1]. Maillard JY. Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance. J Appl Microbiol. 2022 Dec;133(6):3322-3346. [Content Brief]
[2]. Yip KW, et al. Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen. Clin Cancer Res. 2006 Sep 15;12(18):5557-69. [Content Brief]
[3]. Sreevidya VS, et al. Benzalkonium chloride, benzethonium chloride, and chloroxylenol - Three replacement antimicrobials are more toxic than triclosan and triclocarban in two model organisms. Environ Pollut. 2018 Apr;235:814-824. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.2317 mL | 11.1587 mL | 22.3174 mL | 55.7936 mL |
| 5 mM | 0.4463 mL | 2.2317 mL | 4.4635 mL | 11.1587 mL | |
| 10 mM | 0.2232 mL | 1.1159 mL | 2.2317 mL | 5.5794 mL | |
| 15 mM | 0.1488 mL | 0.7439 mL | 1.4878 mL | 3.7196 mL | |
| 20 mM | 0.1116 mL | 0.5579 mL | 1.1159 mL | 2.7897 mL | |
| 25 mM | 0.0893 mL | 0.4463 mL | 0.8927 mL | 2.2317 mL | |
| 30 mM | 0.0744 mL | 0.3720 mL | 0.7439 mL | 1.8598 mL | |
| 40 mM | 0.0558 mL | 0.2790 mL | 0.5579 mL | 1.3948 mL | |
| DMSO | 50 mM | 0.0446 mL | 0.2232 mL | 0.4463 mL | 1.1159 mL |
| 60 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9299 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Benzethonium chloride 関連分類
HY-B0942 関連分類
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