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製品番号: HY-169871

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Argiotoxin 636

Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 105029-41-2
分子式: C₂₉H₅₂N₁₀O₆
分子量:636.79

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Argiotoxin 636 構造式

CAS 番号: 105029-41-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

iGluR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	0.23 μM Compound: ArgTx-636	Inhibition of GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.23 μM Compound: ArgTx-636	Inhibition of recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.35 μM Compound: ArgTx-636	Inhibition of GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.35 μM Compound: ArgTx-636	Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.43 μM Compound: ArgTx-636	Inhibition of GluA4 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of GluA4 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.43 μM Compound: ArgTx-636	Inhibition of recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	135 nM Compound: ArgTX-636, 1	Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay	[PMID: 23092360]
Oocyte	IC₅₀	177 nM Compound: ArgTX-636, 1	Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay	[PMID: 23092360]
Oocyte	IC₅₀	3.4 μM Compound: ArgTx-636	Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	3.4 μM Compound: ArgTx-636	Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current	[PMID: 20096591]
Oocyte	IC₅₀	300 μM Compound: ArgTx-636	Activity at recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay Activity at recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	300 μM Compound: ArgTx-636	Inhibition of rat recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current Inhibition of rat recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current	[PMID: 20096591]
Oocyte	IC₅₀	5.5 μM Compound: ArgTx-636	Inhibition of recombinant GluA1A2 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA1A2 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	74 nM Compound: ArgTX-636	Inhibition of rat GluN1/2A expressed in xenopus laevis oocytes assessed as inhibition of glycine-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology Inhibition of rat GluN1/2A expressed in xenopus laevis oocytes assessed as inhibition of glycine-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology	[PMID: 21188966]
Oocyte	IC₅₀	77 nM Compound: ArgTX-636	Inhibition of rat GluA1 expressed in xenopus laevis oocytes assessed as inhibition of glutamate-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology Inhibition of rat GluA1 expressed in xenopus laevis oocytes assessed as inhibition of glutamate-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology	[PMID: 21188966]

化学情報

CAS 番号 105029-41-2
分子量 636.79
分子式 C₂₉H₅₂N₁₀O₆
SMILES

N=C(N)NCCC[C@H](N)C(NCCCNCCCNCCCCCNC([C@H](CC(N)=O)NC(CC1=C(C=C(C=C1)O)O)=O)=O)=O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Animals
- Animal Venoms
Argiope aurantia
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Adams ME, et al. Structures and biological activities of three synaptic antagonists from orb weaver spider venom. Biochem Biophys Res Commun. 1987 Oct 29;148(2):678-83. [Content Brief]

[2]. Ashe JH, et al. Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons. Brain Res. 1989 Feb 20;480(1-2):234-41. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Argiotoxin 636

iGluR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Argiotoxin 636 関連分類

HY-169871 関連分類