CDK7-IN-28
CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication.
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- CAS 番号: 3034082-58-8
- 分子式: C23H27F3N6O
- 分子量:460.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CDK7/Cyclin H/MNAT1 ＜5 nM (IC50) |
cdk2/cyclin A 6224 nM (IC50) |
CDK9/CyclinA 296 nM (IC50) |
CDK13/Cyclin K 152 nM (IC50) |
CDK7-IN-28 applies to MDA-MB-468 cells (IC50=2 nM), HepaRG cells (IC50 < 10 nM), NAl-H82 (IC50< 10 nM) has good antiproliferative activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:
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Concentration:
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Incubation Time:
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Result:
化学情報
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CAS 番号 3034082-58-8
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分子量 460.50
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分子式 C23H27F3N6O
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SMILES
FC(F)(C1=CN=C(N=C1C2=CNC3=C2CCCN(C3=O)C4CC4)N[C@@H]5CNC6(CC5)CC6)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK7-IN-28 関連分類
HY-158170 関連分類
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