Dazdotuftide TFA
Dazdotuftide TFA (TRS01 TFA) is a multi-target immunomodulator composed of tuftsin and phosphorylcholine-related groups. Dazdotuftide TFA regulates TLR4/NF-κB and NRP1/VEGF165 related signaling pathways and inhibits the production of pro-inflammatory cytokines. Dazdotuftide TFA can be used in studies related to inflammation and immunoregulation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2522933-45-3
- 分子式: C43H68N13O13P.xC2HF3O2
- 分子量:1006.05 (free base)
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
TLR4 |
NRP1 |
体外実験
Dazdotuftide TFA (TRS01 TFA) reduces the production of IL-1β, IL-2, IL-5, IL-6, IL-9, IL-12 (p70), IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IFNγ, TNFα and GM-CSF in CD3/CD28-activated human PBMCs, with negligible effects on cell viability.[1]
Dazdotuftide TFA reduces the production of IL-1β, IL-6, IL-13 and IL-17A, and decreases CD68 gene expression in inflammatory human temporal artery biopsies[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2522933-45-3
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分子量 1006.05 (free base)
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分子式 C43H68N13O13P.xC2HF3O2
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別名
TRS01 TFA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Vofo BN, et al. Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate. Biomedicines. 2023 May 27;11(6):1562. [Content Brief]
[2]. Tungsattayathitthan U, et al. Emerging therapeutic targets in non-infectious uveitis and scleritis. Frontiers in medicine. 2026;13:1846374. [Content Brief]
[3]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dazdotuftide TFA 関連分類
HY-P3449A 関連分類
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