Abl1 - c-abl oncogene 1, non-receptor tyrosine kinase Gene

Also Known as Abl; c-Abl; E430008G22Rik

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 11350

About Abl1

Chromosome 2: 31,578,388-31,694,239 forward strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 204 orthologues, 32 paralogues and is associated with 66 phenotypes. Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues.

Summary

Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of blood vessel branching; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Abl1 Products (5)

mRNA	Protein	Name
NM_001283045.1	NP_001269974.1	tyrosine-protein kinase ABL1 isoform c
NM_001283046.1	NP_001269975.1	tyrosine-protein kinase ABL1 isoform d
NM_001283047.1	NP_001269976.1	tyrosine-protein kinase ABL1 isoform e
NM_001112703.2	NP_001106174.1	tyrosine-protein kinase ABL1 isoform a
NM_009594.4	NP_033724.2	tyrosine-protein kinase ABL1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ATP binding	IDA IDA: Inferred from direct assay	9109492	MGI
enables actin filament binding	IDA IDA: Inferred from direct assay	11864995	MGI
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	24658113	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	12379650	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9109492	MGI
enables manganese ion binding	IDA IDA: Inferred from direct assay	9109492	MGI
enables neuropilin binding	IPI IPI: Inferred from physical interaction	24863063	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8861907	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	8438166	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	11864995	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	24863063	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9109492	MGI
enables protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	18827006	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	10825157	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within B cell proliferation	IMP IMP: Inferred from mutant phenotype	19228876	MGI
acts upstream of or within B cell proliferation involved in immune response	IGI IGI: Inferred from genetic interaction	7671324	MGI
acts upstream of or within B cell proliferation involved in immune response	IMP IMP: Inferred from mutant phenotype	8806812	MGI
acts upstream of or within B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11120811	MGI
acts upstream of or within B-1 B cell homeostasis	IMP IMP: Inferred from mutant phenotype	19228876	MGI
acts upstream of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	22729085	MGI
acts upstream of or within Bergmann glial cell differentiation	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of or within DN4 thymocyte differentiation	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22729085	MGI
acts upstream of or within T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	18305217	MGI
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11279004	MGI
acts upstream of or within activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18025176	MGI
acts upstream of or within alpha-beta T cell differentiation	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of cell-cell adhesion	IGI IGI: Inferred from genetic interaction	24367707	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	8806812	MGI
acts upstream of cellular senescence	IGI IGI: Inferred from genetic interaction	22729085	MGI
acts upstream of or within cerebellum morphogenesis	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of or within circulatory system development	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within establishment of localization in cell	IGI IGI: Inferred from genetic interaction	23100514	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	22665498	MGI
acts upstream of interleukin-2 production	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of or within microspike assembly	IDA IDA: Inferred from direct assay	11864995	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	22729085	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22729085	MGI
acts upstream of or within negative regulation of cell-cell adhesion	IGI IGI: Inferred from genetic interaction	24367707	MGI
acts upstream of or within negative regulation of cellular senescence	IGI IGI: Inferred from genetic interaction	22729085	MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process	IGI IGI: Inferred from genetic interaction	23840065	MGI
involved in negative regulation of long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	24658113	MGI
acts upstream of or within negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	8612582	MGI
acts upstream of or within negative regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	8612582	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within neuroepithelial cell differentiation	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20823226	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	20417104	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9109492	MGI
acts upstream of or within phagocytosis	IGI IGI: Inferred from genetic interaction	23100514	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	22665498	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	20417104	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18827006	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18827006	MGI
involved in positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	22810897	MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	20837657	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19805123	MGI
involved in positive regulation of blood vessel branching	IMP IMP: Inferred from mutant phenotype	24863063	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	18025176	MGI
involved in positive regulation of cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	24863063	MGI
involved in positive regulation of establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	22810897	MGI
acts upstream of or within positive regulation of interleukin-2 production	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20823226	MGI
acts upstream of or within positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	22729085	MGI
acts upstream of or within positive regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	19228876	MGI
acts upstream of or within positive regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	9883720	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21690296	MGI
involved in regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	21690296	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	11809706	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10805805	MGI
acts upstream of or within regulation of cellular senescence	IGI IGI: Inferred from genetic interaction	22729085	MGI
acts upstream of or within regulation of extracellular matrix organization	IGI IGI: Inferred from genetic interaction	20980600	MGI
involved in regulation of modification of synaptic structure	IGI IGI: Inferred from genetic interaction	24658113	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	17626041	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	2065352	MGI
acts upstream of or within substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11864995	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	2065352	MGI
acts upstream of or within transitional one stage B cell differentiation	IMP IMP: Inferred from mutant phenotype	19228876	MGI
acts upstream of type II interferon production	IGI IGI: Inferred from genetic interaction	18025176	MGI

Cellular Component GO Annotation	Evidence	参考文献	由来
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11864995	MGI
located in cell leading edge	IDA IDA: Inferred from direct assay	20417104	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9636171	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8612582	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Abl1 Protein Structure

SH3_Abl

SH2_ABL

PTKc_Abl

FABD

0
200
400
600
800
1000
1123 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase ABL1	Abelson murine leukemia oncogene Abelson tyrosine-protein kinase 1 abelson murine leukemia viral oncogene homolog 1 c-abl oncogene 1, receptor tyrosine kinase c-abl protein, type I c-abl protein, type II c-abl protein, type III p150 proto-oncogene c-Abl proto-oncogene tyrosine-protein kinase ABL1 v-abl Abelson murine leukemia oncogene 1

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-104010	Asciminib	Inhibitor	99.61%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.79%	Yes
HY-15728	Radotinib		99.19%	Yes

Clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Phase
HY-13024	Rebastinib		99.84%	Phase 2
HY-137460	Vodobatinib	Inhibitor	98.09%	Phase 2
HY-148794	Risvodetinib	Inhibitor	99.21%	Phase 2
HY-13072	Cenisertib	Inhibitor	99.86%	Phase 1

Pre-clinical Phase

Bioactive Molecules (50)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-125834	GMB-475		98.69%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.05%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-153996	CT1113		99.61%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-145887	BCR-ABL1-IN-1		99.82%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-12338	ON 146040	Inhibitor	95.05%	Unkown
HY-130297	PROTAC BCR-ABL1 ligand 1	Inhibitor	99.17%	Unkown
HY-13072R	Cenisertib (Standard)	Inhibitor	99.87%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-13024A	Rebastinib tosylate		/	Unkown
HY-184100S	Relcobatinib	Inhibitor	/	Unkown
HY-107447S	N-Deshydroxyethyl Dasatinib-d8		/	Unkown
HY-101268	CHMFL-ABL-053	Inhibitor	/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-104010S	Asciminib-d4	Inhibitor	/	Unkown
HY-119177	PD173956	Inhibitor	/	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-155112	Antiproliferative agent-30	Inhibitor	/	Unkown
HY-156745	PROTAC DDa-1	Degrader	/	Unkown
HY-15728S	Radotinib-d6		/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162489	Tyrosine kinase-IN-8	Inhibitor	/	Unkown
HY-162952	cSRC/BCR-ABL1-IN-1	Inhibitor	/	Unkown
HY-171146	HSN748	Inhibitor	/	Unkown
HY-175281	SJ11646		/	Unkown
HY-179247	BCR-ABL1-IN-2	Inhibitor	/	Unkown
HY-179460	Radotinib dihydrochloride		/	Unkown
HY-181839	DDR1/2 IN-4	Inhibitor	/	Unkown
HY-182792	Embibatinib	Inhibitor	/	Unkown
HY-185227	EphB4-IN-1	Inhibitor	/	Unkown
HY-18819	BCR-ABL-IN-2	Inhibitor	/	Unkown
HY-E70634	ABL1 E255K Recombinant Human Active Protein Kinase		/	Unkown
HY-E70635	ABL1 F317I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70636	ABL1 G250E Recombinant Human Active Protein Kinase		/	Unkown
HY-E70637	ABL1 H396P Recombinant Human Active Protein Kinase		/	Unkown
HY-E70638	ABL1 M351T Recombinant Human Active Protein Kinase		/	Unkown
HY-E70639	ABL1 Q252H Recombinant Human Active Protein Kinase		/	Unkown
HY-E70640	ABL1 T315I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70641	ABL1 Y253F Recombinant Human Active Protein Kinase		/	Unkown
HY-RS00102	ABL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00103	Abl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00104	ABL1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13072B	Cenisertib benzoate	Inhibitor	/	Unkown
HY-14142	AP-24226	Inhibitor	/	Unkown
HY-181046	Multi-kinase-IN-14		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Abl1	NCBI	NCBI:25