BCR-ABL1-IN-1
Based on 1 Customer Validation
BCR-ABL1-IN-1 (Example 74) is the inhibitor for ABL1 (64-515) with IC50 of 8.7 nM. BCR-ABL1-IN-1 can be used in research on diseases related to the central nervous system (CNS).
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 1488090-21-6
- Formula: C18H12F3N3O2
- Molecular Weight:359.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Abl1 8.7 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
69 nM
Compound: 4
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Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
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[PMID: 35065232] |
| BaF3 | IC50 |
75 nM
Compound: 4
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Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
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[PMID: 35065232] |
BCR-ABL1-IN-1 inhibits the proliferation of cell Ba/F3-BCR-ABL1-WT with IC50 of 30 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1488090-21-6
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Appearance Solid
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Molecular Weight 359.30
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Formula C18H12F3N3O2
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Color White to off-white
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SMILES
O=C(C1=CN=CC(C2=CC=CN=C2)=C1)NC3=CC=C(C=C3)OC(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 175 mg/mL (487.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7832 mL | 13.9159 mL | 27.8319 mL | 69.5797 mL |
| 5 mM | 0.5566 mL | 2.7832 mL | 5.5664 mL | 13.9159 mL | |
| 10 mM | 0.2783 mL | 1.3916 mL | 2.7832 mL | 6.9580 mL | |
| 15 mM | 0.1855 mL | 0.9277 mL | 1.8555 mL | 4.6386 mL | |
| 20 mM | 0.1392 mL | 0.6958 mL | 1.3916 mL | 3.4790 mL | |
| 25 mM | 0.1113 mL | 0.5566 mL | 1.1133 mL | 2.7832 mL | |
| 30 mM | 0.0928 mL | 0.4639 mL | 0.9277 mL | 2.3193 mL | |
| 40 mM | 0.0696 mL | 0.3479 mL | 0.6958 mL | 1.7395 mL | |
| 50 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3916 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4639 mL | 1.1597 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8697 mL | |
| 100 mM | 0.0278 mL | 0.1392 mL | 0.2783 mL | 0.6958 mL |
BCR-ABL1-IN-1 Related Classifications
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