BCR-ABL1-IN-1
Based on 1 Customer Validation
BCR-ABL1-IN-1 (Example 74) is the inhibitor for ABL1 (64-515) with IC50 of 8.7 nM. BCR-ABL1-IN-1 can be used in research on diseases related to the central nervous system (CNS).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- CAS 番号: 1488090-21-6
- 分子式: C18H12F3N3O2
- 分子量:359.30
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Abl1 8.7 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
69 nM
Compound: 4
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Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
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[PMID: 35065232] |
| BaF3 | IC50 |
75 nM
Compound: 4
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Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
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[PMID: 35065232] |
BCR-ABL1-IN-1 inhibits the proliferation of cell Ba/F3-BCR-ABL1-WT with IC50 of 30 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1488090-21-6
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性状 Solid
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分子量 359.30
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分子式 C18H12F3N3O2
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Color White to off-white
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SMILES
O=C(C1=CN=CC(C2=CC=CN=C2)=C1)NC3=CC=C(C=C3)OC(F)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 175 mg/mL (487.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7832 mL | 13.9159 mL | 27.8319 mL | 69.5797 mL |
| 5 mM | 0.5566 mL | 2.7832 mL | 5.5664 mL | 13.9159 mL | |
| 10 mM | 0.2783 mL | 1.3916 mL | 2.7832 mL | 6.9580 mL | |
| 15 mM | 0.1855 mL | 0.9277 mL | 1.8555 mL | 4.6386 mL | |
| 20 mM | 0.1392 mL | 0.6958 mL | 1.3916 mL | 3.4790 mL | |
| 25 mM | 0.1113 mL | 0.5566 mL | 1.1133 mL | 2.7832 mL | |
| 30 mM | 0.0928 mL | 0.4639 mL | 0.9277 mL | 2.3193 mL | |
| 40 mM | 0.0696 mL | 0.3479 mL | 0.6958 mL | 1.7395 mL | |
| 50 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3916 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4639 mL | 1.1597 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8697 mL | |
| 100 mM | 0.0278 mL | 0.1392 mL | 0.2783 mL | 0.6958 mL |
BCR-ABL1-IN-1 関連分類
HY-145887 関連分類
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