BCR-ABL1-IN-1
Based on 1 Customer Validation
BCR-ABL1-IN-1 (Example 74) is the inhibitor for ABL1 (64-515) with IC50 of 8.7 nM. BCR-ABL1-IN-1 can be used in research on diseases related to the central nervous system (CNS).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.82%
- CAS No.: 1488090-21-6
- Formule: C18H12F3N3O2
- Masse moléculaire:359.30
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Abl1 8.7 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
69 nM
Compound: 4
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Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
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[PMID: 35065232] |
| BaF3 | IC50 |
75 nM
Compound: 4
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Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
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[PMID: 35065232] |
In Vitro
BCR-ABL1-IN-1 inhibits the proliferation of cell Ba/F3-BCR-ABL1-WT with IC50 of 30 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1488090-21-6
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Appearance Solid
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Masse moléculaire 359.30
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Formule C18H12F3N3O2
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Color White to off-white
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SMILES
O=C(C1=CN=CC(C2=CC=CN=C2)=C1)NC3=CC=C(C=C3)OC(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 175 mg/mL (487.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7832 mL | 13.9159 mL | 27.8319 mL | 69.5797 mL |
| 5 mM | 0.5566 mL | 2.7832 mL | 5.5664 mL | 13.9159 mL | |
| 10 mM | 0.2783 mL | 1.3916 mL | 2.7832 mL | 6.9580 mL | |
| 15 mM | 0.1855 mL | 0.9277 mL | 1.8555 mL | 4.6386 mL | |
| 20 mM | 0.1392 mL | 0.6958 mL | 1.3916 mL | 3.4790 mL | |
| 25 mM | 0.1113 mL | 0.5566 mL | 1.1133 mL | 2.7832 mL | |
| 30 mM | 0.0928 mL | 0.4639 mL | 0.9277 mL | 2.3193 mL | |
| 40 mM | 0.0696 mL | 0.3479 mL | 0.6958 mL | 1.7395 mL | |
| 50 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3916 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4639 mL | 1.1597 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8697 mL | |
| 100 mM | 0.0278 mL | 0.1392 mL | 0.2783 mL | 0.6958 mL |
BCR-ABL1-IN-1 Related Classifications
HY-145887 Related Classifications
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