Cenisertib benzoate
Based on 1 publication(s) in Google Scholar
Cenisertib (AS-703569) benzoate is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib benzoate induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib benzoate inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.
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- CAS No.: 1145859-64-8
- Formula: C31H36FN7O3
- Molecular Weight:573.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Cenisertib benzoate
MoreAll Aurora Kinase Isoforms
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Biological Activity
Chemical Information
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CAS No. 1145859-64-8
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Molecular Weight 573.66
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Formula C31H36FN7O3
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SMILES
OC(C1=CC=CC=C1)=O.NC([C@H]2[C@@](C=C3)([H])C[C@@]3([H])[C@H]2NC4=NC(NC5=CC(C)=C(N6CCN(CC6)C)C=C5)=NC=C4F)=O
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Synonyms
AS-703569 benzoate; R-763 benzoate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Peter B, et al. Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells. Leukemia. 2018 Apr;32(4):1016-1022. [Content Brief]
[2]. McLaughlin J, et al. Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. [Content Brief]
[3]. Maryam Shariati, et al. Targeting AKT for cancer therapy. Expert Opin Investig Drugs. 2019 Nov;28(11):977-988. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cenisertib benzoate Related Classifications
HY-13072B Related Classifications
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