Embibatinib
Embibatinib (TERN-701) is an orally active and allosteric BCR-ABL1 tyrosine kinase inhibitor targeting the myristoyl pocket. Embibatinib exhibits an IC50 of 0.38 nM against ABL1 wild-type enzyme. Embibatinib can be used for the study of chronic myeloid leukemia (CML).
For research use only. We do not sell to patients.
- CAS No.: 2412966-86-8
- Formula: C23H18ClF4N5O3
- Molecular Weight:523.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Abl1 0.38 nM (IC50) |
In Vitro
Embibatinib (TERN-701, compound 1) demonstrates potent ABL1 inhibitory activity with an IC50 of 0.38 nM[1].
Embibatinib shows great potency against several BCR-ABL1 resistance mutations. The total IC90 values in KCL22 cell lines are 15.3 ng/mL (sensitive) and 72.2 ng/mL (least sensitive non-T315I)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2412966-86-8
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Molecular Weight 523.87
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Formula C23H18ClF4N5O3
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SMILES
OC[C@H](N1C2=C(C3=CN=CN=C3)C=C(C=C2N=C1C(F)F)C(NC4=CC=C(C=C4)OC(F)(F)Cl)=O)C
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Synonyms
TERN-701
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Embibatinib Related Classifications
HY-182792 Related Classifications
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