Embibatinib
Embibatinib (TERN-701) is an orally active and allosteric BCR-ABL1 tyrosine kinase inhibitor targeting the myristoyl pocket. Embibatinib exhibits an IC50 of 0.38 nM against ABL1 wild-type enzyme. Embibatinib can be used for the study of chronic myeloid leukemia (CML).
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- CAS. Nr.: 2412966-86-8
- Formel: C23H18ClF4N5O3
- Molecular Weight:523.87
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Abl1 0.38 nM (IC50) |
Embibatinib (TERN-701, compound 1) demonstrates potent ABL1 inhibitory activity with an IC50 of 0.38 nM[1].
Embibatinib shows great potency against several BCR-ABL1 resistance mutations. The total IC90 values in KCL22 cell lines are 15.3 ng/mL (sensitive) and 72.2 ng/mL (least sensitive non-T315I)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2412966-86-8
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Molecular Weight 523.87
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Formel C23H18ClF4N5O3
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SMILES
OC[C@H](N1C2=C(C3=CN=CN=C3)C=C(C=C2N=C1C(F)F)C(NC4=CC=C(C=C4)OC(F)(F)Cl)=O)C
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Synonyms
TERN-701
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Embibatinib Related Classifications
HY-182792 Related Classifications
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