2412966-86-8
2412966-86-8
Chemical Structure
Embibatinib
Synonym(s): TERN-701
- CAS No.: 2412966-86-8
- Formula:C23H18ClF4N5O3
- Molecular Weight:523.87
InChIKey: MTFOIMMCUOJPHL-GFCCVEGCSA-N
SMILES: OC[C@H](N1C2=C(C3=CN=CN=C3)C=C(C=C2N=C1C(F)F)C(NC4=CC=C(C=C4)OC(F)(F)Cl)=O)C
Biological Activity: Embibatinib (TERN-701) is an orally active and allosteric BCR-ABL1 tyrosine kinase inhibitor targeting the myristoyl pocket. Embibatinib exhibits an IC50 of 0.38 nM against ABL1 wild-type enzyme. Embibatinib can be used for the study of chronic myeloid leukemia (CML)[1].
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Embibatinib | Embibatinib (TERN-701) is an orally active and allosteric BCR-ABL1 tyrosine kinase inhibitor targeting the myristoyl pocket. Embibatinib exhibits an IC50 of 0.38 nM against ABL1 wild-type enzyme. Embibatinib can be used for the study of chronic myeloid leukemia (CML). | |||||||||||||||||||||
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