2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. PD173956

PD173956 is a pyridopyrimidine Bcr-Abl kinase inhibitor with high selectivity for the P-loop mutant form of Bcr-Abl.

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PD173956

PD173956 Chemical Structure

CAS No. : 305820-76-2

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PD173956 Related Antibodies

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Abl Bcr-Abl

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Description

PD173956 is a pyridopyrimidine Bcr-Abl kinase inhibitor with high selectivity for the P-loop mutant form of Bcr-Abl[1].

Cellular Effect
Cell Line Type Value Description References
HCT-8 IC50
0.662 μM
Compound: PD-0173956
Inhibition of HCT-8 cell proliferation
Inhibition of HCT-8 cell proliferation
[PMID: 10974196]
HCT-8 IC50
0.9 μM
Compound: PD-0173956
Inhibition of HCT-8 clonogenic growth in soft agar with pretreatment
Inhibition of HCT-8 clonogenic growth in soft agar with pretreatment
[PMID: 10974196]
HCT-8 IC50
1.15 μM
Compound: PD-0173956
Inhibition of HCT-8 clonogenic growth in soft agar without pretreatment
Inhibition of HCT-8 clonogenic growth in soft agar without pretreatment
[PMID: 10974196]
HT-29 IC50
0.617 μM
Compound: PD-0173956
Inhibition of HT-29 cell proliferation
Inhibition of HT-29 cell proliferation
[PMID: 10974196]
HT-29 IC50
1.53 μM
Compound: PD-0173956
Inhibition of HT-29 clonogenic growth in soft agar with pretreatment
Inhibition of HT-29 clonogenic growth in soft agar with pretreatment
[PMID: 10974196]
HT-29 IC50
1.54 μM
Compound: PD-0173956
Inhibition of HT-29 clonogenic growth in soft agar without pretreatment
Inhibition of HT-29 clonogenic growth in soft agar without pretreatment
[PMID: 10974196]
Jurkat IC50
3700 nM
Compound: 10
Cytotoxicity against Philadelphia chromosome negative human Jurkat cells by Alamar Blue fluorescent assay
Cytotoxicity against Philadelphia chromosome negative human Jurkat cells by Alamar Blue fluorescent assay
[PMID: 19889540]
K562 IC50
< 10 nM
Compound: 10
Cytotoxicity against Philadelphia chromosome positive human K562 cells by Alamar Blue fluorescent assay
Cytotoxicity against Philadelphia chromosome positive human K562 cells by Alamar Blue fluorescent assay
[PMID: 19889540]
MEG-01 IC50
< 10 nM
Compound: 10
Cytotoxicity against Philadelphia chromosome positive human MEG01 cells by Alamar Blue fluorescent assay
Cytotoxicity against Philadelphia chromosome positive human MEG01 cells by Alamar Blue fluorescent assay
[PMID: 19889540]
SW-620 IC50
0.402 μM
Compound: PD-0173956
Inhibition of SW-620 clonogenic growth in soft agar without pretreatment
Inhibition of SW-620 clonogenic growth in soft agar without pretreatment
[PMID: 10974196]
SW-620 IC50
0.619 μM
Compound: PD-0173956
Inhibition of SW-620 cell proliferation
Inhibition of SW-620 cell proliferation
[PMID: 10974196]
SW-620 IC50
1.55 μM
Compound: PD-0173956
Inhibition of SW-620 clonogenic growth in soft agar with pretreatment
Inhibition of SW-620 clonogenic growth in soft agar with pretreatment
[PMID: 10974196]
Molecular Weight

415.25

Formula

C20H13Cl2FN4O
CAS No.
SMILES

O=C1C(C2=C(C=CC=C2Cl)Cl)=CC3=CN=C(N=C3N1C)NC4=CC=C(C=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD173956 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD173956305820-76-2PD 173956PD-173956Bcr-AblInhibitorinhibitorinhibit

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