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Cat. No.: HY-119177

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PD173956

PD173956 is a pyridopyrimidine Bcr-Abl kinase inhibitor with high selectivity for the P-loop mutant form of Bcr-Abl.

For research use only. We do not sell to patients.

CAS No.: 305820-76-2
Formula: C₂₀H₁₃Cl₂FN₄O
Molecular Weight:415.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PD173956 Chemical Structure

CAS No.: 305820-76-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PD173956 is a pyridopyrimidine Bcr-Abl kinase inhibitor with high selectivity for the P-loop mutant form of Bcr-Abl^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	IC₅₀	0.662 μM Compound: PD-0173956	Inhibition of HCT-8 cell proliferation Inhibition of HCT-8 cell proliferation	[PMID: 10974196]
HCT-8	IC₅₀	0.9 μM Compound: PD-0173956	Inhibition of HCT-8 clonogenic growth in soft agar with pretreatment Inhibition of HCT-8 clonogenic growth in soft agar with pretreatment	[PMID: 10974196]
HCT-8	IC₅₀	1.15 μM Compound: PD-0173956	Inhibition of HCT-8 clonogenic growth in soft agar without pretreatment Inhibition of HCT-8 clonogenic growth in soft agar without pretreatment	[PMID: 10974196]
HT-29	IC₅₀	0.617 μM Compound: PD-0173956	Inhibition of HT-29 cell proliferation Inhibition of HT-29 cell proliferation	[PMID: 10974196]
HT-29	IC₅₀	1.53 μM Compound: PD-0173956	Inhibition of HT-29 clonogenic growth in soft agar with pretreatment Inhibition of HT-29 clonogenic growth in soft agar with pretreatment	[PMID: 10974196]
HT-29	IC₅₀	1.54 μM Compound: PD-0173956	Inhibition of HT-29 clonogenic growth in soft agar without pretreatment Inhibition of HT-29 clonogenic growth in soft agar without pretreatment	[PMID: 10974196]
Jurkat	IC₅₀	3700 nM Compound: 10	Cytotoxicity against Philadelphia chromosome negative human Jurkat cells by Alamar Blue fluorescent assay Cytotoxicity against Philadelphia chromosome negative human Jurkat cells by Alamar Blue fluorescent assay	[PMID: 19889540]
K562	IC₅₀	<10 nM Compound: 10	Cytotoxicity against Philadelphia chromosome positive human K562 cells by Alamar Blue fluorescent assay Cytotoxicity against Philadelphia chromosome positive human K562 cells by Alamar Blue fluorescent assay	[PMID: 19889540]
KU812 cell line	IC₅₀	<10 nM Compound: 10	Cytotoxicity against Philadelphia chromosome positive human KU812 cells by Alamar Blue fluorescent assay Cytotoxicity against Philadelphia chromosome positive human KU812 cells by Alamar Blue fluorescent assay	[PMID: 19889540]
MEG-01	IC₅₀	<10 nM Compound: 10	Cytotoxicity against Philadelphia chromosome positive human MEG01 cells by Alamar Blue fluorescent assay Cytotoxicity against Philadelphia chromosome positive human MEG01 cells by Alamar Blue fluorescent assay	[PMID: 19889540]
SW-620	IC₅₀	0.402 μM Compound: PD-0173956	Inhibition of SW-620 clonogenic growth in soft agar without pretreatment Inhibition of SW-620 clonogenic growth in soft agar without pretreatment	[PMID: 10974196]
SW-620	IC₅₀	0.619 μM Compound: PD-0173956	Inhibition of SW-620 cell proliferation Inhibition of SW-620 cell proliferation	[PMID: 10974196]
SW-620	IC₅₀	1.55 μM Compound: PD-0173956	Inhibition of SW-620 clonogenic growth in soft agar with pretreatment Inhibition of SW-620 clonogenic growth in soft agar with pretreatment	[PMID: 10974196]

Chemical Information

CAS No. 305820-76-2
Molecular Weight 415.25
Formula C₂₀H₁₃Cl₂FN₄O
SMILES

O=C1C(C2=C(C=CC=C2Cl)Cl)=CC3=CN=C(N=C3N1C)NC4=CC=C(C=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Inhibition of Wild-Type and Mutant Bcr-Abl by Pyrido-Pyrimidine-Type Small Molecule Kinase Inhibitors

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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