YWHAB - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Gene

Also Known as HS1; GW128; YWHAA; KCIP-1; HEL-S-1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7529

About YWHAB

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,885,705-44,908,532 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues.

Summary

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

YWHAB Products (2)

mRNA Protein Name
NM_003404.5 NP_003395.1 2014/3/3 protein beta/alpha
NM_139323.4 NP_647539.1 2014/3/3 protein beta/alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables enzyme binding IPI
IPI: Inferred from physical interaction
17255105 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
10869435 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17085597 GOA
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
10869435 GOA
enables phosphoserine residue binding IPI
IPI: Inferred from physical interaction
10869435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7644510 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11984006 GOA
enables protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
11555644 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in cytoplasmic sequestering of protein IDA
IDA: Inferred from direct assay
10869435 GOA
involved in negative regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21224381 GOA
involved in positive regulation of catalytic activity IDA
IDA: Inferred from direct assay
17255105 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
10869435 GOA
located in cytosol IDA
IDA: Inferred from direct assay
31906564 GOA
located in nucleus IDA
IDA: Inferred from direct assay
31906564 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12963375 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YWHAB Protein Structure

14-3-3

14-3-3: 14-3-3 protein (6 - 237)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

14-3-3 protein beta/alpha

  • 14-3-3 alpha

YWHAB Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
YWHAB P31946 CDK14 Homo sapiens O94921
Anti Tag CoIP
36931259
Intra
YWHAB P31946 CDK14 Homo sapiens O94921
Anti Bait CoIP
16775625
Intra
YWHAB P31946 YAP1 Homo sapiens P46937
Anti Tag CoIP
35271311
Intra
YWHAB P31946 YAP1 Homo sapiens P46937
CoIP
17974916
Intra
YWHAB P31946 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra
YWHAB P31946 YAP1 Homo sapiens P46937
BioID
36931259
Intra
YWHAB P31946 PTPN3 Homo sapiens P26045
Anti Tag CoIP
36931259
Intra
YWHAB P31946 PTPN3 Homo sapiens P26045
Anti Tag CoIP
33961781
Intra
YWHAB P31946 PTPN3 Homo sapiens P26045
Anti Bait CoIP
17353931
Intra
YWHAB P31946 CDC25B Homo sapiens P30305
Anti Tag CoIP
33961781
Intra
YWHAB P31946 CDC25B Homo sapiens P30305
CoIP
15173315
Intra
YWHAB P31946 CDC25B Homo sapiens P30305
Y2H
7644510
Intra
YWHAB P31946 DYRK1A Homo sapiens Q13627-2
Y2H
17229891
Intra
YWHAB P31946 RMDN3 Homo sapiens Q96TC7
IF
21972092
Intra
YWHAB P31946 RMDN3 Homo sapiens Q96TC7
Anti Bait CoIP
17353931
Intra
YWHAB P31946 RMDN3 Homo sapiens Q96TC7
PLA
21972092
Intra
YWHAB P31946 RMDN3 Homo sapiens Q96TC7
Anti Tag CoIP
33961781
Intra
YWHAB P31946 RND3 Homo sapiens P61587
Pull Down
23622247
Intra
YWHAB P31946 CRTC2 Homo sapiens Q53ET0
Anti Tag CoIP
24255178
Intra
YWHAB P31946 CRTC2 Homo sapiens Q53ET0
Pull Down
15454081
Intra
YWHAB P31946 CRTC2 Homo sapiens Q53ET0
Anti Tag CoIP
36931259
Intra
YWHAB P31946 CRTC2 Homo sapiens Q53ET0
Anti Tag CoIP
33961781
Intra
YWHAB P31946 CRTC2 Homo sapiens Q53ET0
Anti Tag CoIP
35271311
Intra
YWHAB P31946 SSH1 Homo sapiens Q8WYL5
CoIP
15159416
Intra
YWHAB P31946 AKAP13 Homo sapiens Q12802
Anti Tag CoIP
35271311
Intra
YWHAB P31946 AKAP13 Homo sapiens Q12802
Anti Bait CoIP
17353931
Intra
YWHAB P31946 AKAP13 Homo sapiens Q12802
Anti Tag CoIP
33961781
Intra
YWHAB P31946 AKAP13 Homo sapiens Q12802
BioID
36931259
Intra
YWHAB P31946 ADAM22 Homo sapiens Q9P0K1-3
Anti Tag CoIP
16868027
Intra
YWHAB P31946 ADAM22 Homo sapiens Q9P0K1-3
Y2H
16868027
Intra
YWHAB P31946 ALS2 Homo sapiens A0A0S2Z5Q7
Validated Y2H
32814053
Intra
YWHAB P31946 ALS2 Homo sapiens A0A0S2Z5Q7
Y2H Array
32814053
Intra
YWHAB P31946 ALS2 Homo sapiens A0A0S2Z5Q7
Y2H Pooling
32814053
Intra
YWHAB P31946 SPG11 Homo sapiens Q96JI7
Pull Down
36096339
Intra
YWHAB P31946 MAP3K3 Homo sapiens Q99759
Anti Tag CoIP
36931259
Intra
YWHAB P31946 MAP3K3 Homo sapiens Q99759
Anti Tag CoIP
33961781
Intra
YWHAB P31946 HDAC4 Homo sapiens P56524
Anti Tag CoIP
24255178
Intra
YWHAB P31946 HDAC4 Homo sapiens P56524
BioID
36931259
Intra
YWHAB P31946 HDAC4 Homo sapiens P56524
Anti Tag CoIP
33961781
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
BioID
36931259
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
Anti Tag CoIP
36931259
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
Anti Tag CoIP
35271311
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
SLCA
17085597
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
Y2H Pooling
20936779
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
Anti Tag CoIP
33961781
Intra
YWHAB P31946 YWHAE Homo sapiens P62258
Anti Tag CoIP
24255178
Intra
YWHAB P31946 YWHAG Homo sapiens P61981
Anti Tag CoIP
35271311
Intra
YWHAB P31946 YWHAG Homo sapiens P61981
SLCA
17085597
Intra
YWHAB P31946 YWHAG Homo sapiens P61981
Anti Tag CoIP
33961781
Intra
YWHAB P31946 YWHAG Homo sapiens P61981
Anti Tag CoIP
24255178
Intra
YWHAB P31946 YWHAQ Homo sapiens P27348
Anti Tag CoIP
35271311
Intra
YWHAB P31946 YWHAQ Homo sapiens P27348
SLCA
17085597
Intra
YWHAB P31946 YWHAQ Homo sapiens P27348
Anti Tag CoIP
33961781
Intra
YWHAB P31946 YWHAQ Homo sapiens P27348
Anti Tag CoIP
24255178
Intra
YWHAB P31946 BRAF Homo sapiens P15056
Anti Tag CoIP
24255178
Intra
YWHAB P31946 BRAF Homo sapiens P15056
Anti Tag CoIP
33961781
Intra
YWHAB P31946 BRAF Homo sapiens P15056
BioID
36931259
Intra
YWHAB P31946 BRAF Homo sapiens P15056
Anti Bait CoIP
17353931
Intra
YWHAB P31946 ZNF395 Homo sapiens Q9H8N7
CoIP
17531190
Intra
YWHAB P31946 ZNF395 Homo sapiens Q9H8N7
Anti Tag CoIP
33961781
Intra
YWHAB P31946 DACT1 Homo sapiens Q9NYF0
Y2H
21262972
Intra
YWHAB P31946 DACT1 Homo sapiens Q9NYF0
Anti Tag CoIP
21262972
Intra
YWHAB P31946 DACT1 Homo sapiens Q9NYF0
Anti Bait CoIP
21262972
Intra
YWHAB P31946 TSC2 Homo sapiens P49815
Pull Down
12438239
Intra
YWHAB P31946 TSC2 Homo sapiens P49815
Anti Tag CoIP
24255178
Intra
YWHAB P31946 TSC2 Homo sapiens P49815
Anti Tag CoIP
33961781
Intra
YWHAB P31946 TSC2 Homo sapiens P49815
BioID
36931259
Intra
YWHAB P31946 TSC2 Homo sapiens P49815
Anti Bait CoIP
17353931
Intra
YWHAB P31946 TSC2 Homo sapiens P49815
Anti Tag CoIP
35271311
Intra
YWHAB P31946 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
YWHAB P31946 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
YWHAB P31946 HTT Homo sapiens P42858
Y2H
17500595
Intra
YWHAB P31946 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
YWHAB P31946 MAP3K5 Homo sapiens Q99683
Anti Tag CoIP
35271311
Intra
YWHAB P31946 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
16959763
Intra
YWHAB P31946 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
36931259
Intra
YWHAB P31946 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
33961781
Intra
YWHAB P31946 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
24255178
Intra
YWHAB P31946 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
35271311
Intra
YWHAB P31946 CBL Homo sapiens P22681
Anti Tag CoIP
36931259
Intra
YWHAB P31946 CBL Homo sapiens P22681
Anti Tag CoIP
33961781
Intra
YWHAB P31946 CBL Homo sapiens P22681
Anti Tag CoIP
24255178
Intra
YWHAB P31946 CBL Homo sapiens P22681
Biochemical
11697890
Intra
YWHAB P31946 LRRK2 Homo sapiens Q5S007
Protein Array
24947832
Intra
YWHAB P31946 SRPK2 Homo sapiens P78362
CoIP
19592491
Intra
YWHAB P31946 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Cross
YWHAB P31946 Zfp36 Mus musculus P22893
CoIP
14688255
Cross
YWHAB P31946 Rnd3 Mus musculus P61588
Anti Tag CoIP
23622247
Cross
YWHAB P31946 Rnd3 Mus musculus P61588
Pull Down
23622247
Intra
YWHAB P31946 BAD Homo sapiens Q92934
Anti Tag CoIP
33961781
Intra
YWHAB P31946 BAD Homo sapiens Q92934
Anti Tag CoIP
24255178
Intra
YWHAB P31946 BAD Homo sapiens Q92934
Anti Tag CoIP
36931259
Intra
YWHAB P31946 MARK3 Homo sapiens P27448
Anti Tag CoIP
35271311
Intra
YWHAB P31946 MARK3 Homo sapiens P27448
Anti Bait CoIP
17353931
Intra
YWHAB P31946 MARK3 Homo sapiens P27448
Anti Tag CoIP
24255178
Intra
YWHAB P31946 MARK3 Homo sapiens P27448
Anti Tag CoIP
36931259
Intra
YWHAB P31946 MARK3 Homo sapiens P27448
Anti Tag CoIP
33961781
Intra
YWHAB P31946 MARK3 Homo sapiens P27448
BioID
36931259
Cross
YWHAB P31946 Gem Mus musculus P55041
Pull Down
15860732
Cross
YWHAB P31946 Gem Mus musculus P55041
Pull Down
14701738
Intra
YWHAB P31946 AKT1S1 Homo sapiens Q96B36
Anti Tag CoIP
24255178
Intra
YWHAB P31946 AKT1S1 Homo sapiens Q96B36
Pull Down
18372248
Intra
YWHAB P31946 AKT1S1 Homo sapiens Q96B36
Anti Tag CoIP
33961781
Intra
YWHAB P31946 AKT1S1 Homo sapiens Q96B36
Anti Tag CoIP
36931259
Intra
YWHAB P31946 CBX4 Homo sapiens O00257
Anti Bait CoIP
22078878
Intra
YWHAB P31946 CBX4 Homo sapiens O00257
BioID
36931259
Intra
YWHAB P31946 GEM Homo sapiens P55040
Pull Down
14701738
Intra
YWHAB P31946 CDC25A Homo sapiens P30304
Y2H
7644510
Intra
YWHAB P31946 CDC25A Homo sapiens P30304
Pull Down
7644510
Intra
YWHAB P31946 CDC25A Homo sapiens P30304
Anti Bait CoIP
7644510
Cross
YWHAB P31946 Synpo2 Mus musculus Q91YE8
Pull Down
15883195
Intra
YWHAB P31946 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
YWHAB P31946 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
YWHAB P31946 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
YWHAB P31946 ATXN1 Homo sapiens P54253
BioID
36931259
Intra
YWHAB P31946 CDC25C Homo sapiens P30307
Anti Tag CoIP
33961781
Intra
YWHAB P31946 CDC25C Homo sapiens P30307
Anti Tag CoIP
24255178
Intra
YWHAB P31946 CDC25C Homo sapiens P30307
Anti Tag CoIP
35271311
Intra
YWHAB P31946 CDC25C Homo sapiens P30307
Anti Tag CoIP
36931259
Intra
YWHAB P31946 CHEK1 Homo sapiens O14757
Anti Tag CoIP
35271311
Intra
YWHAB P31946 CHEK1 Homo sapiens O14757
Pull Down
20639859
Intra
YWHAB P31946 GAB2 Homo sapiens Q9UQC2
CoIP
19172738
Intra
YWHAB P31946 GAB2 Homo sapiens Q9UQC2
Anti Tag CoIP
33961781
Intra
YWHAB P31946 GAB2 Homo sapiens Q9UQC2
BioID
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YWHAB Proteins

製品番号 製品名 アクセッション番号 純度
HY-P74439 14-3-3 beta Protein, Human (GST) P31946 (M1-N246) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74440 14-3-3 beta Protein, Human P31946 (M1-N246) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700304 14-3-3 beta Protein, Human (His) P31946 (M1-N246) ≥ 95%, as determined by reducing SDS-PAGE.

YWHAB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82204 14-3-3 beta Antibody (YA1949) WB Human, Rat
HY-P84258 14-3-3 beta Antibody (YA3955) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat
HY-P84258A 14-3-3 beta Antibody (YA3955)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat

関連疾患

Diseases Alias
Chlamydia

  • Chlamydial Infection

  • Chlamydia Trachomatis Infectious Disease

  • Chlamydial Disease

  • Chlamydia Infections
Eosinophilic Meningitis

  • Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Hyperinsulinemic Hypoglycemia, Familial, 5

  • Hyperinsulinism Due To Insr Deficiency

  • HHF5

  • Familial Hyperinsulinemic Hypoglycemia 5

  • Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

  • Congenital Hyperinsulinism

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • Hyperinsulinemic Hypoglycemia Familial 5
Chronic Meningitis
Lymphogranuloma Venereum

  • Climatic Or Tropical Bubo

  • Durand-Nicolas-Favre Disease

  • Lymphogranuloma Inguinale

  • Poradenitis Inguinale

  • Strumous Bubo

  • Lgv
Granuloma Inguinale

  • Donovanosis

  • Pudendal Ulcer

  • Granuloma Inguinale Tropicum

  • Granuloma Pudendi Tropicum
Chromosome 17p13.3, Centromeric, Duplication Syndrome

  • Chromosome 17p13.3 Duplication Syndrome

  • 17p13.3 Duplication Syndrome

  • 17p13.3 Microduplication Syndrome

  • Trisomy 17p13.3

  • Chromosome 17p13.3 Centromeric Duplication Syndrome

  • Dup(17)(P13.3)
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15940 YWHAB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19757 Ywhab Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26254 Ywhab Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris YWHAB VGNC VGNC:48508
Rattus norvegicus YWHAB RGD RGD:61998
Mus musculus YWHAB MGD MGI:1891917
Felis catus YWHAB VGNC VGNC:67154
Macaca mulatta YWHAB VGNC VGNC:78819
Bos taurus YWHAB VGNC VGNC:37044
Others YWHAB NCBI