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PIGZ - phosphatidylinositol glycan anchor biosynthesis class Z Gene

Also Known as SMP3; PIG-Z; GPI-MT-IV

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 80235

About PIGZ

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,946,356-196,968,833 (from NCBI)

This gene has 4 transcripts (splice variants) and 43 orthologues. Broad expression in colon (RPKM 5.3), brain (RPKM 1.9) and 20 other tissues.

Summary

The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]

PIGZ Products (1)

mRNA	Protein	Name
NM_025163.4	NP_079439.2	GPI mannosyltransferase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables alpha-1,2-mannosyltransferase activity	IMP IMP: Inferred from mutant phenotype	15208306	GOA
enables mannosyltransferase activity	EXP EXP: Inferred from Experiment	15208306	GOA
enables mannosyltransferase activity	IGI IGI: Inferred from genetic interaction	15208306	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in GPI anchor biosynthetic process	IGI IGI: Inferred from genetic interaction	15208306	GOA
involved in GPI anchor biosynthetic process	IMP IMP: Inferred from mutant phenotype	15208306	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15208306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIGZ Protein Structure

Glyco_transf_22

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
GPI mannosyltransferase 4	GPI mannosyltransferase IV

関連疾患

Diseases	Alias
Thyroid Dyshormonogenesis 5	TDH5 Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5 Thyroid Hormonogenesis, Genetic Defect In, 5 Genetic Defect In Thyroid Hormonogenesis 5 Chdh5 Congenital Hypothyroidism Due To Dyshormonogenesis Type 5 Genetic Defect In Thyroid Hormonogenesis Type 5
Developmental And Epileptic Encephalopathy 80	DEE80 Glycosylphosphatidylinositol Biosynthesis Defect 20 Gpibd20 Epileptic Encephalopathy, Early Infantile, 80 Eiee80 Developmental And Epileptic Encephalopathy, 80 Early Infantile Epileptic Encephalopathy 80
Familial Thyroid Dyshormonogenesis	Thyroid Dyshormonogenesis Familial Dyshormonogenetic Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS10508	PIGZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	PIGZ	MGD	MGI:2443822
Macaca mulatta	PIGZ	VGNC	VGNC:75899
Rattus norvegicus	PIGZ	RGD	RGD:1307107
Bos taurus	PIGZ	VGNC	VGNC:32882
Others	PIGZ	NCBI