Lyso-PAF C-16-d4
Lyso-PAF C-16-d4 (Lyso-platelet-activating factor C-16-d4) is the deuterated-labeled Lyso-PAF C-16 (HY-141570). Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase.
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- CAS 番号: 201216-37-7
- 分子式: C24H48D4NO6P
- 分子量:485.67
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Phospholipase アイソフォーム固有の製品をすべて表示
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生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 201216-37-7
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非標識Cas 52691-62-0
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性状 Liquid
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分子量 485.67
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分子式 C24H48D4NO6P
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Color Colorless to light yellow
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SMILES
CCCCCCCCC([2H])([2H])C([2H])([2H])CCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
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別名
Lyso-platelet-activating factor C-16-d4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
純度とドキュメンテーション
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データシート (263 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Grosman N, et al. Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. Int Immunopharmacol. 2001;1(7):1321-1329. [Content Brief]
[2]. Uemura Y, et al. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem. 1991 May 5;266(13):8268-72. [Content Brief]
[3]. Venable ME, et al. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. J Biol Chem. 1993 Apr 15;268(11):7965-75. [Content Brief]
[4]. Yamaura S, et al. Novel enzymatic method for assaying Lp-PLA2 in serum. Clin Chim Acta. 2018 Jun;481:184-188. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lyso-PAF C-16-d4 関連分類
HY-141570S 関連分類
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- Lyso-PAF C-16-d4
- 201216-37-7
- Lyso-platelet-activating factor C-16-d4
- Isotope-Labeled Compounds
- Phospholipase
- rat brain synaptosomal membranes
- Ca2+-ATPase
- rat mixed peritoneal leukocyte membranes
- rat peritoneal leukocyte membrane
- allergic reactions
- inflammatory reactions
- ether phospholipid derivative
- plasma membrane Ca2+-ATPase
- Inhibitor
- inhibitor
- inhibit