Meayamycin B
Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1020210-12-1
- 分子式: C31H48N2O8
- 分子量:576.72
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Mcl-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.49 nM
Compound: 96
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Cytotoxicity against human HCT-116 cells assessed as inhibition in cell growth
Cytotoxicity against human HCT-116 cells assessed as inhibition in cell growth
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[PMID: 33974423] |
| HCT-116/VM46 | IC50 |
0.55 nM
Compound: 96
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Cytotoxicity against human HCT116/VM46 cells assessed as inhibition in cell growth
Cytotoxicity against human HCT116/VM46 cells assessed as inhibition in cell growth
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[PMID: 33974423] |
| L1210 | IC50 |
7.8 nM
Compound: 96
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Cytotoxicity against mouse L1210 cells assessed as inhibition in cell growth
Cytotoxicity against mouse L1210 cells assessed as inhibition in cell growth
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[PMID: 33974423] |
化学情報
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CAS 番号 1020210-12-1
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分子量 576.72
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分子式 C31H48N2O8
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SMILES
O[C@H]1[C@@]2(CC(C)(O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(N4CCOCC4)=O)=O)C)C)CO2
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別名
(+)-Meayamycin B
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Meayamycin B 関連分類
HY-15867 関連分類
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