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製品番号: HY-N21575

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Milliamine C

Milliamine C is a diterpenoid ester of the euphane type that inhibits the specific binding of phorbol-12,13-dipropionate to mouse epidermal particulate fractions and induces skin irritation, but exhibits very weak or undetectable tumor-promoting activity. Milliamine C can be used in studies related to skin tumor promotion.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 49620-09-9
分子式: C₄₃H₄₇N₃O₉
分子量:749.85

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Milliamine C 構造式

CAS 番号: 49620-09-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Milliamine C (compound 4) inhibits the binding of [³H]-PDPr to cellular diterpene ester receptors^[1].
Milliamine C (10 nM; 20 min) strongly inhibits the specific binding of [³H]-PDPr to epidermal particulate fractions from NMRI mice, with a K_i50 of 2.3 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Milliamine C (compound 4) (20 nmol; topical; twice weekly) does not exhibit tumor-promoting activity on mouse back skin^[1].
Milliamine C (topical; single administration) is a potent irritant on the mouse ear, with an ID₅₀²⁴ of 0.0066 nmol^[1].
Milliamine C (topical; single administration; measured at 24 h) acts as a strong skin irritant in NMRI mice, with an ID₅₀²⁴ of 0.007 nmol/ear^[2].
Milliamine C exhibits acute toxicity in mice, with an LD₁₀₀ of 0.64 mg/kg^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI mice^[1]
Dosage:

20 nmol
Administration:

topical; twice per week
Result:

Exhibited no tumour promoting activity in the standard initiation/promotion experiment at a dose of 20 nmol applied twice per week.

化学情報

CAS 番号 49620-09-9
分子量 749.85
分子式 C₄₃H₄₇N₃O₉
SMILES

O=C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(CO)=C[C@](C3=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Marston A, et al. On the Active Principles of the Euphorbiaceae VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii. Planta Med. 1983, 47(3).

[2]. Schmidt R, et al. Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin. Carcinogenesis. 1983;4(1):77-81.

[3]. Yoshimasa Hirata. STRUCTURES AND BIOLOGICAL ACTIVITIES OF SOME TOXIC NATURAL PRODUCTS. Chemistry for the Welfare of Mankind, Pergamon, 1979, Pages 979-986, ISBN 9780080220079,

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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