49620-09-9
Chemical Structure
Milliamine C
- CAS No.: 49620-09-9
- Formula:C43H47N3O9
- Molecular Weight:749.85
IUPAC Name: 5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-6-yl 2-(2-(2-(dimethylamino)benzamido)-3-hydroxybenzamido)benzoate
InChIKey: NWUXCAUIAMSMJQ-ZABBLZTKSA-N
SMILES: O=C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(CO)=C[C@](C3=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Biological Activity: Milliamine C is a diterpenoid ester of the euphane type that inhibits the specific binding of phorbol-12,13-dipropionate to mouse epidermal particulate fractions and induces skin irritation, but exhibits very weak or undetectable tumor-promoting activity. Milliamine C can be used in studies related to skin tumor promotion[1][2][3].
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Milliamine C | Milliamine C is a diterpenoid ester of the euphane type that inhibits the specific binding of phorbol-12,13-dipropionate to mouse epidermal particulate fractions and induces skin irritation, but exhibits very weak or undetectable tumor-promoting activity. Milliamine C can be used in studies related to skin tumor promotion. | |||||||||||||||||||||
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References
- [1]. Marston A, et al. On the Active Principles of the Euphorbiaceae VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii. Planta Med. 1983, 47(3).
- [2]. Schmidt R, et al. Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin. Carcinogenesis. 1983;4(1):77-81.
- [3]. Yoshimasa Hirata. STRUCTURES AND BIOLOGICAL ACTIVITIES OF SOME TOXIC NATURAL PRODUCTS. Chemistry for the Welfare of Mankind, Pergamon, 1979, Pages 979-986, ISBN 9780080220079,
