NLRP3-IN-84

NLRP3-IN-84 (Compound 32) is a NLRP3 inflammasome inhibitor. NLRP3-IN-84 can interfere with the oligomerization process of NLRP3 by inhibiting the activity of NLRP3 ATPase (IC₅₀ = 158.4 nM). NLRP3-IN-84 inhibits Caspase-1 (IC₅₀ = 27.7 nM), IL-1β release (PBMC: IC₅₀ = 19.5 nM; mPBMC: IC₅₀ = 24.2 nM), and ASC plaque formation (IC₅₀ = 131 nM). NLRP3-IN-84 has no inhibitory activity on NLRC4 and AIM2 inflammasomes. NLRP3-IN-84 exhibits significant in vivo anti-inflammatory effects in a mouse acute peritonitis model. NLRP3-IN-84 can be used for the study of NLRP3-related inflammatory diseases.

• Data Sheet (268 KB)