製品番号: HY-101071

(S)-Monastrol

(別名: (+)-Monastrol)

(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.

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CAS 番号: 254753-54-3
分子式: C₁₄H₁₆N₂O₃S
分子量:292.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(S)-Monastrol 構造式

CAS 番号: 254753-54-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Kinesin アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4 μg/mL Compound: BA2, monastrol	Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
A-431	IC₅₀	53 μg/mL Compound: Monastrol	Cytotoxicity against human A431 cells after 48 hrs by MTT assay Cytotoxicity against human A431 cells after 48 hrs by MTT assay	[PMID: 21620531]
A549	IC₅₀	>10 μM Compound: Monastrol	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 21856161]
A549	IC₅₀	>100 μM Compound: 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
A549	IC₅₀	118 μg/mL Compound: Monastrol	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21620531]
AGS	IC₅₀	>10 μM Compound: Monastrol	Cytotoxicity against human AGS cells after 48 hrs by SRB assay Cytotoxicity against human AGS cells after 48 hrs by SRB assay	[PMID: 21856161]
BXPC-3	EC₅₀	>100 nM Compound: rac-monastrol	Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
C6	IC₅₀	>200 μM Compound: 1	Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay	[PMID: 30108989]
C6	IC₅₀	87.83 μM Compound: Manastrol	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30151081]
COLO 205	IC₅₀	164 μg/mL Compound: Monastrol	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay	[PMID: 21620531]
HCT-116	EC₅₀	1.2 μM Compound: monastrol	Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy	[PMID: 18793847]
HCT-116	EC₅₀	1.5 μM Compound: monastrol	Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy	[PMID: 18793847]
HCT-116	EC₅₀	24155 nM Compound: rac-monastrol	Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
HCT-116	IC₅₀	>50 μM Compound: Monastrol	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 20934346]
HCT-116	IC₅₀	9 μM Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
HeLa	IC₅₀	176.9 μM Compound: Monastrol	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29908443]
HeLa	IC₅₀	51.3 μM Compound: 1, monastrol	Induction of monoastral spindles in HeLa cells after 7 hrs Induction of monoastral spindles in HeLa cells after 7 hrs	[PMID: 17587586]
HeLa	IC₅₀	6.1 μM Compound: 1, monastrol	Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs	[PMID: 17587586]
HL-60(TB)	IC₅₀	0.147 μM Compound: Monastrol	Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay	[PMID: 28667871]
HT-29	GI₅₀	29.6 μg/mL Compound: BA2, monastrol	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
K562	EC₅₀	>100 nM Compound: rac-monastrol	Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
KB 3-1	EC₅₀	56494 nM Compound: rac-monastrol	Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar	[PMID: 20597485]
KB 3-1	EC₅₀	85114 nM Compound: rac-monastrol	Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
KB-V1	EC₅₀	45394 nM Compound: rac-monastrol	Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar	[PMID: 20597485]
KB-V1	EC₅₀	99083 nM Compound: rac-monastrol	Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay	[PMID: 20597485]
MCF7	IC₅₀	45 μg/mL Compound: Monastrol	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21620531]
MCF7	IC₅₀	59.1 μM Compound: Monastrol	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29908443]
MCF7	IC₅₀	73 μM Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MM1.S	IC₅₀	8.7 μM Compound: 1	Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MOLT-4	IC₅₀	0.215 μM Compound: Monastrol	Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay	[PMID: 28667871]
NCI/ADR-RES	GI₅₀	22.2 μg/mL Compound: BA2, monastrol	Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
NCI-H1299	EC₅₀	>100 nM Compound: rac-monastrol	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
NCI-H460	GI₅₀	10.6 μg/mL Compound: BA2, monastrol	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
OVCAR-3	GI₅₀	14.4 μg/mL Compound: BA2, monastrol	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
PC-3	GI₅₀	5.6 μg/mL Compound: BA2, monastrol	Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
U138-MG	IC₅₀	>200 μM Compound: 1	Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay	[PMID: 30108989]
U-251	GI₅₀	24 μg/mL Compound: BA2, monastrol	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]

化学情報

CAS 番号 254753-54-3
分子量 292.35
分子式 C₁₄H₁₆N₂O₃S
SMILES

O=C(C1=C(C)NC(N[C@H]1C2=CC=CC(O)=C2)=S)OCC
別名

(+)-Monastrol
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288. [Content Brief]

[2]. Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(S)-Monastrol

Kinesin アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

(S)-Monastrol 関連分類

HY-101071 関連分類