Sterigmatocystine
Based on 1 Customer Validation
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.74%
- CAS 番号: 10048-13-2
- 分子式: C18H12O6
- 分子量:324.28
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Microbial Metabolite |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
3.63 μM
Compound: 7
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Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay
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[PMID: 24251417] |
| MDA-MB-231 | IC50 |
2.75 μM
Compound: 7
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay
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[PMID: 24251417] |
| NCI-H460 | IC50 |
3.41 μM
Compound: 7
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Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay
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[PMID: 24251417] |
| PC-3M | IC50 |
3.23 μM
Compound: 7
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Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay
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[PMID: 24251417] |
| SF-268 | IC50 |
2.96 μM
Compound: 7
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Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay
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[PMID: 24251417] |
Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 10048-13-2
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性状 Solid
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分子量 324.28
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分子式 C18H12O6
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Color Off-white to light yellow
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SMILES
O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[C@]5([H])[C@@]4([H])C=CO5)C=C2OC
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Structure Classification
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Initial Source
Aspergillus versicolor
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 25 mg/mL (77.09 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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参考文献
[1]. Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31. [Content Brief]
[2]. Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91. [Content Brief]
[3]. Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656. [Content Brief]
[4]. Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0838 mL | 15.4188 mL | 30.8375 mL | 77.0939 mL |
| 5 mM | 0.6168 mL | 3.0838 mL | 6.1675 mL | 15.4188 mL | |
| 10 mM | 0.3084 mL | 1.5419 mL | 3.0838 mL | 7.7094 mL | |
| 15 mM | 0.2056 mL | 1.0279 mL | 2.0558 mL | 5.1396 mL | |
| 20 mM | 0.1542 mL | 0.7709 mL | 1.5419 mL | 3.8547 mL | |
| 25 mM | 0.1234 mL | 0.6168 mL | 1.2335 mL | 3.0838 mL | |
| 30 mM | 0.1028 mL | 0.5140 mL | 1.0279 mL | 2.5698 mL | |
| 40 mM | 0.0771 mL | 0.3855 mL | 0.7709 mL | 1.9273 mL | |
| 50 mM | 0.0617 mL | 0.3084 mL | 0.6168 mL | 1.5419 mL | |
| 60 mM | 0.0514 mL | 0.2570 mL | 0.5140 mL | 1.2849 mL |
Sterigmatocystine 関連分類
HY-N6725 関連分類
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