Sucrose octasulfate
Sucrose octasulfate, a derivative of sulfated oligosaccharides, is a matrix metalloproteinase (MMP) inhibitor. Sucrose octasulfate stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by acting directly on D cells in the gastric mucosa. Sucrose octasulfate exerts its ulcer-healing effect by releasing endogenous gastric somatostatin. Sucrose octasulfate can be used as a pharmaceutical excipient and significantly improves wound closure in diabetic foot ulcers caused by nerve ischemia and venous leg ulcers. Sucrose octasulfate can be used in the study of chronic wound healing.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 57680-56-5
- 分子式: C12H22O35S8
- 分子量:982.80
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Sucrose octasulfate (2.5-20 mg/mL; 2 h) dose-dependently stimulates somatostatin-like immunoreactivity release from isolated canine gastric fundic D-cells, potentiating epinephrine-induced release at 10 and 20 mg/mL but only adding to gastrin heptadecapeptide-induced release[3].
Sucrose octasulfate (2.5-20 mg/mL; 2 h) potentiates dibutyryl cyclic adenosine 3',5'-monophosphate-induced somatostatin-like immunoreactivity release from isolated canine gastric fundic D-cells, but does not potentiate 12-O-tetradecanoylphorbol 13-acetate-induced release[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 57680-56-5
-
分子量 982.80
-
分子式 C12H22O35S8
-
SMILES
O=S(OC[C@@]1([C@H]([C@@H]([C@H](O1)COS(=O)(O)=O)OS(=O)(O)=O)OS(=O)(O)=O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COS(=O)(O)=O)OS(=O)(O)=O)OS(=O)(O)=O)OS(=O)(O)=O)(O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Edmonds M, et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196. [Content Brief]
[2]. Dissemond J, et al. Sucrose Octasulfat – Evidenz in der Behandlung chronischer Wunden [Sucrose octasulfate-evidence in the treatment of chronic wounds]. Hautarzt. 2020 Oct;71(10):791-801. German. [Content Brief]
[3]. Lucey MR, et al. Sucrose octasulfate stimulates gastric somatostatin release. Am J Med. 1991 Aug 8;91(2A):52S-57S. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sucrose octasulfate 関連分類
HY-137273A 関連分類
Powered by Bioz