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製品番号: HY-123565

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TP-S1-68

TP-S1-68 (Compound 10) is a TIE-2 inhibitor with an IC₅₀ of 3.65 μM. TP-S1-68 exhibits antibacterial activity against a variety of fungal and bacteria. TP-S1-68 serves as a starting compound for the further development of TIE-2 inhibitors. TP-S1-68 can be used in research related to solid tumors, bacterial infections and fungal infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 120187-04-4
分子式: C₁₅H₉ClN₄S
分子量:312.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

TP-S1-68 構造式

CAS 番号: 120187-04-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

Tie2

3.65 μM (IC₅₀)

Tie アイソフォーム固有の製品をすべて表示 :

Tie1
Tie2

体外実験

TP-S1-68 inhibits the activity of purified recombinant human TIE-2 kinase with an IC₅₀ of 3.650 μM, and suppresses 101.62% of the kinase activity at a concentration of 5 μg/mL^[1].
TP-S1-68 (Compound 5a) exhibits antimicrobial activity against the bacteria Staphylococcus aureus (MTCC 3160), Staphylococcus epidermidis (MTCC 435), Bacillus cereus (MTCC 9786), Escherichia coli (MTCC 118), Klebsiella pneumoniae (MTCC 3384), Pseudomonas aeruginosa (MTCC 4673), and the fungi Candida albicans (MTCC 1637) and Aspergillus niger (MTCC 282), with MIC values of 6.25, 6.25, 6.25, 12.5, 12.5, 12.5, 6.25, and 6.25 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 120187-04-4
分子量 312.78
分子式 C₁₅H₉ClN₄S
SMILES

ClC=1C=CC(=CC1)C2=NN=C3SC(=NN32)C=4C=CC=CC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pan P, et al. Identification and Preliminary SAR Analysis of Novel Type-I Inhibitors of TIE-2 via Structure-Based Virtual Screening and Biological Evaluation in in vitro Models. J Chem Inf Model. 2015;55(12):2693-2704. [Content Brief]

[2]. Jagdish K. Sahu, et al. Synthesis, SAR and Molecular Docking Studies of Certain New Derivatives of 1,2,4-Triazolo [3,4-b][1,3,4] Thiadiazole as Potent Antimicrobial Agents. Anti-Infective Agents, 2018, 16, 40-48.

[3]. Shawali, A. S.,, et al.. Tandem regioselective 1,5-electrocyclizations of bis-nitrilimines—a new convenient synthesis of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. Journal of Sulfur Chemistry, 27(3), 233–244.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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TP-S1-68

Tie アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

TP-S1-68 関連分類

HY-123565 関連分類