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Cat. No.: HY-14828

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Afacifenacin

Name: Afacifenacin
Brand: MedChemExpress
SKU: HY-14828
Price: 646.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: SMP-986)

Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 877606-63-8
화학식: C₂₇H₂₆F₃N₃O₂
분자량:481.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Afacifenacin Chemical Structure

CAS No.: 877606-63-8

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vivo
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All mAChR Isoforms :

In Vivo

Afacifenacin (0.3, 1, 3 mg/kg; Intragastric administration) significantly increases bladder capacity and reduced micturition pressure (MP) in cerebral infarction rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (cerebral infarction model)^[2]
Dosage:

0.3, 1, 3 mg/kg
Administration:

Intragastric administration
Result:

Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 877606-63-8
분자량 481.51
화학식 C₂₇H₂₆F₃N₃O₂
SMILES

O=C1NC2=C(C=CC=C2)[C@H](C3=CC=CC=C3)N1C4CCN(CC5=CC=CC(OC(F)(F)F)=C5)CC4
Synonyms

SMP-986
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yeo EK, et al. New therapies in the treatment of overactive bladder. Expert Opin Emerg Drugs. 2013 Sep;18(3):319-37. [Content Brief]

[2]. Natsuko Goto, et al. Dual inhibition of Na+-channel and muscarinic receptor by SMP-986 efficiently improved voiding function compared to anti-muscarinic agents in two conscious rat models of detrusor overactivity. The Journal of Urology. 2008, 179, 129.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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