32981-86-5
Chemical Structure
10-Deacetylbaccatin III
- CAS No.: 32981-86-5
- Formula:C29H36O10
- Molecular Weight:544.59
IUPAC Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
InChIKey: YWLXLRUDGLRYDR-ZHPRIASZSA-N
SMILES: CC1=C([C@@H](O)C([C@@]2(C)[C@@]3([H])[C@@](CO4)(OC(C)=O)[C@@]4([H])C[C@@H]2O)=O)C(C)(C)[C@@]([C@H]3OC(C5=CC=CC=C5)=O)(O)C[C@@H]1O
Biological Activity: 10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits antileishmanial activity[1][2][3][4][5][6].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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10-Deacetylbaccatin III | 99.96% | 10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits antileishmanial activity. | ||||||||||||||||||||
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10-Deacetylbaccatin III (Standard) | 99.79% | 10-Deacetylbaccatin III (Standard) is the analytical standard of 10-Deacetylbaccatin III. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26. [Content Brief]
- [2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56. [Content Brief]
- [3]. Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6. [Content Brief]
- [4]. Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97（25）：13591-13596.
- [5]. Georgopoulou K, et al. In Vitro Activity of 10-Deacetylbaccatin III against Leishmania donovani Promastigotes and Intracellular Amastigotes. Planta Med, 2007, 73(11):1081-1088. [Content Brief]
- [6]. Patel R N et al. Enzymatic acetylation of 10-deacetylbaccatin III to baccatin III by C-10 deacetylase from Nocardioides luteus SC 13913. Enzyme and Microbial Technology, 2000, 27(5):371-375. [Content Brief]
