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Cat. No.: HY-184877

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CDK4-IN-8

CDK4-IN-8 is a selective CDK4 inhibitor with no activity against CDK6, and it inhibits the proliferation of breast cancer cells. CDK4-IN-8 can be used in breast cancer-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2764984-10-1
화학식: C₂₇H₃₁FN₆OS
분자량:506.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK4-IN-8 Chemical Structure

CAS No.: 2764984-10-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Bioz

Biological Activity

제품 설명

CDK4-IN-8 is a selective CDK4 inhibitor with no activity against CDK6, and it inhibits the proliferation of breast cancer cells. CDK4-IN-8 can be used in breast cancer-related research^[1].

IC₅₀ & Target^[1]

CDK4

All CDK Isoforms :

In Vitro

CDK4-IN-8 (example 98) exhibits potent inhibitory activity against CDK4_D1 kinase, shows moderate antiproliferative activity against MCF7 adenocarcinoma cells, and has no obvious inhibitory activity against CDK6_D1 kinase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2764984-10-1
분자량 506.64
화학식 C₂₇H₃₁FN₆OS
SMILES

O=C1C2=C(SC(C=3N=C(N=CC3F)NC4=NC=C(C=C4)C5CCN(C)CC5)=C2C)C(=CN1C)C(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Buesking A W, et al. Cdk inhibitors and their use as pharmaceuticals. WO2022061273A1. WIPO. 2022.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
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CDK4-IN-8

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CDK4-IN-8 Related Classifications

HY-184877 Related Classifications