ALDH3A1 - aldehyde dehydrogenase 3 family member A1 Gene

Also Known as ALDH3; ALDHIII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 218

About ALDH3A1

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,737,984-19,748,298 (from NCBI)

This gene has 17 transcripts (splice variants), 370 orthologues and 17 paralogues. Biased expression in esophagus (RPKM 74.7), stomach (RPKM 49.1) and 1 other tissue.

Summary

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

ALDH3A1 Products (6)

mRNA	Protein	Name
NM_001135167.1	NP_001128639.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001330150.2	NP_001317079.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform 2
NM_001135168.1	NP_001128640.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
XM_011523731.3	XP_011522033.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform X2
XM_047435595.1	XP_047291551.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform X1
NM_000691.5	NP_000682.3	aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables alcohol dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	1737758	GOA
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	1737758	GOA
enables benzaldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	4015840	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular aldehyde metabolic process	IDA IDA: Inferred from direct assay	1737758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH3A1 Protein Structure

Aldedh

0
100
200
300
400
453 a.a.

Protein Preferred Names	Protein Names
aldehyde dehydrogenase, dimeric NADP-preferring	aldehyde dehydrogenase isozyme 3 aldehyde dehydrogenase type III stomach aldehyde dehydrogenase

ALDH3A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ALDH3A1	P30838	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	ALDH3A1	P30838	POT1	Homo sapiens	Q9NUX5	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDH3A1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P7477	ALDH3A1 Protein, Human (HEK293, His)	P30838 (M1-H453)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P75568	ALDH3A1 Protein, Human (sf9, His)	AAH04370.1 (M1-H453)	≥ 90%, as determined by reducing SDS-PAGE.

ALDH3A1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81375	ALDH3A1 Antibody (YA1120)	IHC-P	Human
HY-P81375A	ALDH3A1 Antibody (YA1120)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Hyperprolinemia	Proline Oxidase Deficiency Hyperprolinemia Type 1 Proline Hydrogenase Deficiency Prolinemia Pyrroline Carboxylate Dehydrogenase Deficiency Pyrroline-5-Carboxylate Dehydrogenase Deficiency Proline Dehydrogenase Deficiency Hyperprolinemia Type 2
Sjogren-Larsson Syndrome	Sjögren-Larsson Syndrome SLS Faldh Deficiency Fatty Aldehyde Dehydrogenase Deficiency Fatty Acid Alcohol Oxidoreductase Deficiency Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia Sjogren Larsson Syndrome Fatty Alcohol:Nad+ Oxidoreductase Deficiency Sjogren-Larsson'S Syndrome Fadh Deficiency Fao Deficiency Congenital Icthyosis Mental Retardation Spasticity Syndrome Ichthyosis Oligophrenia Syndrome Sjoegren-Larsson Syndrome
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-B0364A	Dyclonine hydrochloride		99.12%	Unkown

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-123962	G6PD activator AG1		99.54%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.43%	Unkown
HY-144670	ALDH3A1-IN-1	Inhibitor	99.85%	Unkown
HY-W017186	ALDH1A3-IN-3	Inhibitor	99.26%	Unkown
HY-122577	EN40	Inhibitor	99.33%	Unkown
HY-144669	ALDH1A3-IN-2	Inhibitor	99.85%	Unkown
HY-146683	KS106		99.87%	Unkown
HY-146682	KS100		99.61%	Unkown
HY-RS00571	ALDH3A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-128299	ALDH3A1-IN-4	Inhibitor	99.91%	Unkown
HY-134917	Aldi-2	Inhibitor	/	Unkown
HY-144671	ALDH3A1-IN-2	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-184776	Dyclonine		/	Unkown
HY-B0364AS	Dyclonine-d9 hydrochloride		/	Unkown
HY-RS00572	Aldh3a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00573	Aldh3a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00575	ALDH3B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21982	Aldh3b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28499	Aldh3b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALDH3A1	RGD	RGD:2088
Canis familiaris	ALDH3A1	VGNC	VGNC:37786
Macaca mulatta	ALDH3A1	VGNC	VGNC:69786
Mus musculus	ALDH3A1	MGD	MGI:1353451
Bos taurus	ALDH3A1	VGNC	VGNC:25813
Felis catus	ALDH3A1	VGNC	VGNC:59736
Others	ALDH3A1	NCBI