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Cat. No.: HY-187630

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KNI-174

KNI-174 is a potent and selective HIV-1 protease inhibitor and antiviral agent. KNI-174 targets and inhibits HIV-1-specific aspartic protease, thereby blocking retroviral proliferation. KNI-174 can be used in research related to acquired immunodeficiency syndrome (AIDS).

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CAS No.: 141804-42-4
화학식: C₃₆H₄₅N₅O₇S
분자량:691.84

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

KNI-174 Chemical Structure

CAS No.: 141804-42-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

HIV-1

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
ATH-8 cell line	IC50	276 ng/mL	HIV-1 antiviral activity against ATH8 cells, quantified as inhibition of HIV-1 replication. HIV-1 antiviral activity against ATH8 cells, quantified as inhibition of HIV-1 replication.	8490108

In Vitro

KNI-174 potently inhibits HIV-1 replication in the ATH8 cell line with an IC₅₀ of 276 ng/mL (0.40 μM)^[1].
KNI-174 potently inhibits HIV-1 replication in PHA-PBM with an IC₅₀ of 138 ng/mL (0.20 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2 (Elimination)	CL_total	V₁	V_dss	MRT	AUC_0-last	AUC_0-∞	T_1/2 (Distribution)
Rat^[1]	10.0 mg/kg	i.v.	3.97 h	9.53 mL/min	544 mL/kg	7070 mL/kg	3.14 h	4.42 μg·h/mL	4.80 μg·h/mL	5.07 min

Chemical Information

CAS No. 141804-42-4
분자량 691.84
화학식 C₃₆H₄₅N₅O₇S
SMILES

CC(C)(C)NC([C@H]1N(CSC1(C)C)C([C@@H](O)[C@@H](NC([C@H](CC(N)=O)NC(COC2=CC=CC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kiriyama A, et al. Pharmacokinetic study of a tripeptide HIV-1 protease inhibitor, KNI-174, in rats after intravenous and intraduodenal administrations. Biopharmaceutics & drug disposition. 1993 Apr;14(3):199-207.

[2]. Kiriyama A, et al. Comparison of a new orally potent tripeptide HIV-1 protease inhibitor (anti-AIDS drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations. Biopharmaceutics & drug disposition. 1993 Nov;14(8):697-707.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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