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Cat. No.: HY-N21575

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Milliamine C

Milliamine C is a diterpenoid ester of the euphane type that inhibits the specific binding of phorbol-12,13-dipropionate to mouse epidermal particulate fractions and induces skin irritation, but exhibits very weak or undetectable tumor-promoting activity. Milliamine C can be used in studies related to skin tumor promotion.

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CAS No.: 49620-09-9
화학식: C₄₃H₄₇N₃O₉
분자량:749.85

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Milliamine C Chemical Structure

CAS No.: 49620-09-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Milliamine C (compound 4) inhibits the binding of [³H]-PDPr to cellular diterpene ester receptors^[1].
Milliamine C (10 nM; 20 min) strongly inhibits the specific binding of [³H]-PDPr to epidermal particulate fractions from NMRI mice, with a K_i50 of 2.3 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Milliamine C (compound 4) (20 nmol; topical; twice weekly) does not exhibit tumor-promoting activity on mouse back skin^[1].
Milliamine C (topical; single administration) is a potent irritant on the mouse ear, with an ID₅₀²⁴ of 0.0066 nmol^[1].
Milliamine C (topical; single administration; measured at 24 h) acts as a strong skin irritant in NMRI mice, with an ID₅₀²⁴ of 0.007 nmol/ear^[2].
Milliamine C exhibits acute toxicity in mice, with an LD₁₀₀ of 0.64 mg/kg^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI mice^[1]
Dosage:

20 nmol
Administration:

topical; twice per week
Result:

Exhibited no tumour promoting activity in the standard initiation/promotion experiment at a dose of 20 nmol applied twice per week.

Chemical Information

CAS No. 49620-09-9
분자량 749.85
화학식 C₄₃H₄₇N₃O₉
SMILES

O=C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(CO)=C[C@](C3=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Marston A, et al. On the Active Principles of the Euphorbiaceae VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii. Planta Med. 1983, 47(3).

[2]. Schmidt R, et al. Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin. Carcinogenesis. 1983;4(1):77-81.

[3]. Yoshimasa Hirata. STRUCTURES AND BIOLOGICAL ACTIVITIES OF SOME TOXIC NATURAL PRODUCTS. Chemistry for the Welfare of Mankind, Pergamon, 1979, Pages 979-986, ISBN 9780080220079,

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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