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Cat. No.: HY-122130

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SCH 2047069

Name: SCH 2047069
Brand: MedChemExpress
SKU: HY-122130
Availability: PreOrder

(Synonyms: MK-8267)

SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (K_d: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC₅₀ value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma.

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CAS No.: 1146209-50-8
화학식: C₂₀H₁₇F₄N₃O₂S
분자량:439.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SCH 2047069 Chemical Structure

CAS No.: 1146209-50-8

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Kinesin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	EC₅₀	3 nM Compound: 29, MK-8267	Inhibition of KSP in human HCT116 cells assessed as phos-histone H3 level by immunofluorescent assay Inhibition of KSP in human HCT116 cells assessed as phos-histone H3 level by immunofluorescent assay	[PMID: 25868746]

Chemical Information

CAS No. 1146209-50-8
분자량 439.43
화학식 C₂₀H₁₇F₄N₃O₂S
SMILES

CC(N1N=C(C2=CC(F)=CC=C2F)S[C@@]31[C@H](CCN)COC4=CC(F)=C(F)C=C34)=O
Synonyms

MK-8267
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Basso AD, et al. SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics. Mol Cancer Ther. 2010 Nov;9(11):2993-3002. [Content Brief]

[2]. Nyamaa B, et al. Kinesin spindle protein inhibition in translational research. Journal of Lipid and Atherosclerosis, 2014, 3(2): 63-78.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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