Isotope-Labeled Oxygenated Hydrocarbons

2,5-Hexanedione-d₁₀ (2,5-HD-d₁₀) is the deuterium labeled 2,5-Hexanedione. Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent. Hexane-2,5-dione reduces BCL-2 and β-catenin/TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases.

2-Undecanone-d₅ is the deuterium labeled 2-Undecanone (HY-W016969). 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections.

2-Decanone-d₅-1 is the deuterium labeled 2-Decanone (HY-W010203). 2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables.

2-Decanone-d₅ is deuterated labeled 2-Decanone.

Heptyl methyl ketone-d₅ is the deuterium labeled Heptyl methyl ketone.

1-Octen-3-one-d₃ is deuterated labeled 1-Octen-3-one.

1-Octen-3-one-d₅ is deuterated labeled 1-Octen-3-one.

Octan-2-one-d₅ is deuterated labeled Octan-2-one.