Isotope-Labeled Phosphatidylethanolamines (PE)

1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE-d₁₁ is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE.

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d₃₁ is the deuterium labeled 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (HY-W355700). 1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activate mitogen-activated protein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction.

1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine-d₇ is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine.

17:0-16:1 PE-d₅ is deuterium labeled 17:0-16:1 PE.

17:0-18:1 PE-d₅ is deuterium labeled 17:0-18:1 PE.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d₆₂ (1,2-POPE-d₆₂) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.

18:0 LYSO-PE-d₃₅ is the deuterium labeled 18:0 LYSO-PE (HY-103660). 18:0 LYSO-PE is a lysophospholipid that can induce [Ca²⁺]_i increase.

1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine-d₄₆ (DLPE-d₄₆; 1,2-Dilauroyl-sn-glycero-3-PE-d₄₆) is the deuterium labeled 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE; 1,2-Dilauroyl-sn-glycero-3-PE) is an anionic phospholipid. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine promotes the endocytosis of liposome-DNA complexes into target cells, and subsequently mediates membrane fusion between liposome carriers and endosomes to deliver DNA into the nucleus. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a component of anionic artificial viral envelope liposomes, which deliver plasmid DNA to hepatoma cells without serum inhibition. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine enables the construction of biocompatible non-viral gene delivery vector systems. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is applicable for liposome synthesis.

1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d₂₇ (14:0 Lyso PE-d₂₇) is the deuterium labeled 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine. 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells .

1-Palmitoyl-d₉-2-hydroxy-sn-glycero-3-PE is the deuterium labeled 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE.

1-Palmitoyl-2-hydroxy-sn-glycero-3-PE-d₃₁ is the deuterium labeled 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE (HY-141617). 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring choline phospholipid that can be synthesized from phosphatidylcholine and fatty acids. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is used as a structure-related lipid control.

06:0 PE-d₂₂ (PE(6:0/6:0)-d₂₂) is the deuterium labeled 06:0 PE (HY-W040293). 06:0 PE (PE(6:0/6:0)) is a water-soluble phospholipid characterized by its short acyl chains, exhibiting notable antitumor activity and the ability to inhibit tumor progression in vivo, alongside antiproliferative and proapoptotic effects, while serving as a precursor for phosphatidylcholine and phosphatidylethanolamine.

DOPE-d₆₂ (Dioleoylphosphatidylethanolamine-d₆₂) is the deuterium labeled DOPE (HY-112005). DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d₉ is deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine. 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phospholipid that is a major component of the lipid bilayer that surrounds cells and provides stability to the membrane.

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d₆₂ is deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine. 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phospholipid that is a major component of the lipid bilayer that surrounds cells and provides stability to the membrane.

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate-d₅₄ is deuterium labeled (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate. (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl

17:0-14:1 PE-d₅ is deuterium labeled 17:0-14:1 PE.

17:0-22:4 PE-d₅ is deuterium labeled 17:0-22:4 PE.

19:0 Lyso PE-d₅ is deuterium labeled 19:0 Lyso PE.

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d₇₀ is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis