2. Epigenetics
  3. Histone Demethylase
  4. LSD1-IN-18

LSD1-IN-18 (compound 7) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.156 μM and KD of 0.075 μM, respectively. LSD1-IN-18 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.16 and 0.21 μM, respectively.

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LSD1-IN-18

LSD1-IN-18 Estructura química

No. CAS : 2983011-61-4

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LSD1-IN-18 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Histone Demethylase:

Ver todas las isoformas
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

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Descripciòn

LSD1-IN-18 (compound 7) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.156 μM and KD of 0.075 μM, respectively. LSD1-IN-18 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.16 and 0.21 μM, respectively[1].

IC50 & Target

KDM1/LSD1

 

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
0.21 μM
Compound: 7
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 35525212]
RD IC50
0.9 μM
Compound: 7
Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 144 hrs
Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 144 hrs
[PMID: 35525212]
RD IC50
1.23 μM
Compound: 7
Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 72 hrs
Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 35525212]
RD IC50
2.28 μM
Compound: 7
Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 24 hrs
Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 24 hrs
[PMID: 35525212]
SJRH30 IC50
0.69 μM
Compound: 7
Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 144 hrs
Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 144 hrs
[PMID: 35525212]
SJRH30 IC50
0.91 μM
Compound: 7
Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 72 hrs
Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 35525212]
SJRH30 IC50
1.21 μM
Compound: 7
Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 24 hrs
Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 24 hrs
[PMID: 35525212]
THP-1 IC50
0.092 μM
Compound: 7
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 144 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 144 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 35525212]
THP-1 IC50
0.16 μM
Compound: 7
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 35525212]
THP-1 IC50
0.3 μM
Compound: 7
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 35525212]
Peso molecular

528.69

Fòrmula

C31H40N6O2
No. CAS
SMILES

COC1=CC2=C(C(NC3CCN(CC3)CC4=CC=C5C=CC=CC5=C4)=NC(NCCCN(C)C)=N2)C=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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LSD1-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-182983011-61-4Histone Demethylaselow toxicityTHP-1 cellsMV4-11 cellsMDA-MB-231 cellsbreast cancerMDA-MB-231 TNBC cell lineRMS cellsLysine-specific demethylase 1histone lysine methyltransferasesInhibitorinhibitorinhibit

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Nombre del producto:
LSD1-IN-18
Cat. No.:
HY-146283
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