N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine
N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
For research use only. We do not sell to patients.
- CAS No.: 722505-71-7
- Formula: C18H18F3N5O4
- Molecular Weight:425.36
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine Chemical Structure](https://file.medchemexpress.com/product_pic/hy-152395.gif "Click to View N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| G-361 | IC50 |
>166.7 μM
Compound: 45
|
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| HOS | IC50 |
>166.7 μM
Compound: 45
|
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| K562 | IC50 |
>166.7 μM
Compound: 45
|
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| Vero | CC50 |
>50 μM
Compound: 9
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 7 days by resazurin staining based analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 7 days by resazurin staining based analysis
|
[PMID: 38128296] |
Chemical Information
-
CAS No. 722505-71-7
-
Molecular Weight 425.36
-
Formula C18H18F3N5O4
-
SMILES
O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C3=NC=NC(NCC4=CC=C(C(F)(F)F)C=C4)=C3N=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]
[2]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine Related Classifications
HY-152395 Related Classifications
Powered by Bioz