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Cat. No.: HY-162786

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Nurr1 agonist 11

Nurr1 agonist 11 (compound 53) is a selective and potent Nurr1 agonist with an IC₅₀ of 26 µM. Nurr1 agonist 11 has the ability to cross a cellular model of the blood-brain-barrier (BBB) .

For research use only. We do not sell to patients.

CAS No.: 1090335-04-8
Formula: C₂₀H₂₀N₂O₂
Molecular Weight:320.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Nurr1 agonist 11 Chemical Structure

CAS No.: 1090335-04-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Nuclear Hormone Receptor 4A/NR4A Isoforms :

Chemical Information

CAS No. 1090335-04-8
Molecular Weight 320.39
Formula C₂₀H₂₀N₂O₂
SMILES

CN(C(CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Willems S, et al. Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. J Med Chem. 2024 Aug 8;67(15):13324-13348. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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Nurr1 agonist 11

All Nuclear Hormone Receptor 4A/NR4A Isoforms