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Cat. No.: HY-10458R

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PF-562271 besylate (Standard)

Name: PF-562271 besylate (Standard)
Brand: MedChemExpress
SKU: HY-10458R
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: VS-6062 (besylate) (Standard))

PF-562271 besylate (Standard) is the analytical standard of PF-562271 besylate (HY-10458). This product is intended for research and analytical applications. PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC₅₀ of 1.5 nM and 13 nM, respectively.

For research use only. We do not sell to patients.

Purity: 95%
CAS No.: 939791-38-5
Formula: C₂₇H₂₆F₃N₇O₆S₂
Molecular Weight:665.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PF-562271 besylate (Standard) Chemical Structure

CAS No.: 939791-38-5

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 939791-38-5
Molecular Weight 665.66
Formula C₂₇H₂₆F₃N₇O₆S₂
SMILES

CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O.O=S(C5=CC=CC=C5)(O)=O
Synonyms

VS-6062 (besylate) (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944. [Content Brief]

[2]. Lim ST, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7(15), 2306-2314. [Content Brief]

[3]. Canel M, et al. Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res, 2010, 70(22), 9413-9422. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PF-562271 besylate (Standard)