Picosulfate sodium salt hydrate
Based on 1 publication(s) in Google Scholar
Picosulfate sodium salt hydrate is the hydrate of Sodium Picosulfate (HY-B0544). Picosulfate sodium salt hydrate is an orally active contact irritant laxative. Picosulfate sodium salt hydrate inhibits the absorption of water and electrolytes, increasing their production. Picosulfate sodium salt hydrate can be used in colonoscopy applications.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1307301-38-7
- Formula: C18H15NNa2O9S2
- Molecular Weight:499.42
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Picosulfate sodium salt hydrate
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Biological Activity
Chemical Information
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CAS No. 1307301-38-7
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Appearance Solid
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Molecular Weight 499.42
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Formula C18H15NNa2O9S2
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Color White to off-white
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SMILES
O=S(OC(C=C1)=CC=C1C(C2=CC=CC=N2)C3=CC=C(OS(=O)(O[Na])=O)C=C3)(O[Na])=O.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
2025 Oct 8;33(10):1715-1730.e5. PMID: 40961933
Solvent & Solubility
DMSO : 100 mg/mL (200.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Nishikawa J, et al. Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung. 1981;31(2):321-5. [Content Brief]
[2]. Geboes K, et al. Effects of 'contact laxatives' on intestinal and colonic epithelial cell proliferation. Pharmacology. 1993 Oct;47 Suppl 1:187-95. [Content Brief]
[3]. Fioramonti J, et al. In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology. 1993 Oct;47 Suppl 1:155-61. [Content Brief]
[4]. Regev A, et al. Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution. Am J Gastroenterol. 1998 Sep;93(9):1478-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0023 mL | 10.0116 mL | 20.0232 mL | 50.0581 mL |
| 5 mM | 0.4005 mL | 2.0023 mL | 4.0046 mL | 10.0116 mL | |
| 10 mM | 0.2002 mL | 1.0012 mL | 2.0023 mL | 5.0058 mL | |
| 15 mM | 0.1335 mL | 0.6674 mL | 1.3349 mL | 3.3372 mL | |
| 20 mM | 0.1001 mL | 0.5006 mL | 1.0012 mL | 2.5029 mL | |
| 25 mM | 0.0801 mL | 0.4005 mL | 0.8009 mL | 2.0023 mL | |
| 30 mM | 0.0667 mL | 0.3337 mL | 0.6674 mL | 1.6686 mL | |
| 40 mM | 0.0501 mL | 0.2503 mL | 0.5006 mL | 1.2515 mL | |
| 50 mM | 0.0400 mL | 0.2002 mL | 0.4005 mL | 1.0012 mL | |
| 60 mM | 0.0334 mL | 0.1669 mL | 0.3337 mL | 0.8343 mL | |
| 80 mM | 0.0250 mL | 0.1251 mL | 0.2503 mL | 0.6257 mL | |
| 100 mM | 0.0200 mL | 0.1001 mL | 0.2002 mL | 0.5006 mL |
Picosulfate sodium salt hydrate Related Classifications
HY-107793 Related Classifications
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